Document Detail


Distribution of subcutaneously administered inulin between blood and peripheral lymph in the rabbit.
MedLine Citation:
PMID:  1675274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In experiments on rabbit peripheral lymph, the contribution of the blood and lymphatic system to the whole-body distribution of inulin after subcutaneous administration has been investigated and the effects of hyaluronidase and of thermal stimulus at the administration site examined. Inulin concentrations in lymph exceeded plasma concentrations by more than 100-fold. At the end of the experiment (90 min) the amount of drug in the total lymph collected was about one-seventh the amount found in urine. The blood system, as a result of higher circulation at the administration site distributes inulin from the subcutis more rapidly than does lymph. Hyaluronidase did not influence inulin concentrations in blood and lymph but thermal stimulus significantly decreased both concentration and total distribution. The decrease resulted from a developed oedema and vasoconstriction in the skin and subcutis of the cannulated extremity.
Authors:
J Lamka; V Krejcová; Z Vondrácková; S Gallová; J Kvĕtina
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  43     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-07-18     Completed Date:  1991-07-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  177-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Hradec Králové, Czechoslovakia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Catheterization
Chinchilla
Hindlimb / metabolism
Hot Temperature
Hyaluronoglucosaminidase / diagnostic use
Injections, Subcutaneous
Inulin / blood,  pharmacokinetics*
Lymph / metabolism*
Male
Proteins / metabolism
Rabbits
Chemical
Reg. No./Substance:
0/Proteins; 9005-80-5/Inulin; EC 3.2.1.35/Hyaluronoglucosaminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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