Document Detail

Distribution of sertraline in postmortem cases.
MedLine Citation:
PMID:  7990446     Owner:  NLM     Status:  MEDLINE    
Sertraline is a potent inhibitor of serotonin reuptake in the central nervous system and is used clinically to treat depression and obsessive-compulsive behavior. Over the course of one year, there were seven cases investigated by the Office of the Chief Medical Examiner, State of Maryland, in which sertraline was identified in postmortem specimens. Heart blood concentrations in the seven cases ranged from 0.23 to 0.46 mg/L; desmethylsertraline concentrations ranged from 0.08 to 0.99 mg/L. One similarity with tricyclic antidepressants is the high liver concentrations of drug and metabolite relative to the blood. One unusual finding is the small concentrations of drug and metabolite in the urine relative to other specimens. In none of these cases was the cause of death related to sertraline intoxication.
B Levine; A J Jenkins; J E Smialek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of analytical toxicology     Volume:  18     ISSN:  0146-4760     ISO Abbreviation:  J Anal Toxicol     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-01-06     Completed Date:  1995-01-06     Revised Date:  2008-09-06    
Medline Journal Info:
Nlm Unique ID:  7705085     Medline TA:  J Anal Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  272-4     Citation Subset:  IM    
Office of the Chief Medical Examiner, State of Maryland, Baltimore 21201.
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MeSH Terms
1-Naphthylamine / analogs & derivatives*,  analysis,  pharmacokinetics
Antidepressive Agents / pharmacokinetics*
Chromatography, Gas / instrumentation
Middle Aged
Retrospective Studies
Tissue Distribution
Reg. No./Substance:
0/Antidepressive Agents; 134-32-7/1-Naphthylamine; 79617-96-2/Sertraline; 87857-41-8/desmethylsertraline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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