Document Detail


Distribution of sertraline in postmortem cases.
MedLine Citation:
PMID:  7990446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sertraline is a potent inhibitor of serotonin reuptake in the central nervous system and is used clinically to treat depression and obsessive-compulsive behavior. Over the course of one year, there were seven cases investigated by the Office of the Chief Medical Examiner, State of Maryland, in which sertraline was identified in postmortem specimens. Heart blood concentrations in the seven cases ranged from 0.23 to 0.46 mg/L; desmethylsertraline concentrations ranged from 0.08 to 0.99 mg/L. One similarity with tricyclic antidepressants is the high liver concentrations of drug and metabolite relative to the blood. One unusual finding is the small concentrations of drug and metabolite in the urine relative to other specimens. In none of these cases was the cause of death related to sertraline intoxication.
Authors:
B Levine; A J Jenkins; J E Smialek
Related Documents :
3819686 - Medicolegal aspects of necrotizing fasciitis of the neck.
2398306 - An unusual occurrence of amniotic fluid embolism.
7550206 - Asthma death induced by ibuprofen.
19150586 - Blood concentrations of clonazepam and 7-aminoclonazepam in forensic cases in denmark f...
20141876 - Fragrance material review on 7-octen-2-ol, 2-methyl-6-methylene-, dihydro derivative.
21134336 - Sources of bias in signals of pharmaceutical safety in pregnancy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of analytical toxicology     Volume:  18     ISSN:  0146-4760     ISO Abbreviation:  J Anal Toxicol     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-01-06     Completed Date:  1995-01-06     Revised Date:  2008-09-06    
Medline Journal Info:
Nlm Unique ID:  7705085     Medline TA:  J Anal Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  272-4     Citation Subset:  IM    
Affiliation:
Office of the Chief Medical Examiner, State of Maryland, Baltimore 21201.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
1-Naphthylamine / analogs & derivatives*,  analysis,  pharmacokinetics
Adult
Aged
Antidepressive Agents / pharmacokinetics*
Chromatography, Gas / instrumentation
Female
Humans
Male
Middle Aged
Retrospective Studies
Sertraline
Tissue Distribution
Chemical
Reg. No./Substance:
0/Antidepressive Agents; 134-32-7/1-Naphthylamine; 79617-96-2/Sertraline; 87857-41-8/desmethylsertraline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Automated Cobas Mira kinetic enzymatic assay for ethylene glycol applied to emergency situations.
Next Document:  Determination of tetramine in postmortem specimens by GC-NPD.