Document Detail


Distribution of pressure-induced fast axonal transport abnormalities in primate optic nerve. An autoradiographic study.
MedLine Citation:
PMID:  6167249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution of transport abnormalities in primate optic nerve from eyes subjected to five hours of pressure elevation (perfusion pressure of 35 mm Hg) was studied. Tissue autoradiography and electron microscopy were used to localize regions of the lamina cribrosa with increased transport interruption. A preferential involvement by this transport abnormality involved the superior, temporal, and inferior portions, to the exclusion of the nasal portion, of the optic nerve head. This observation supports the hypothesis that transport interruption seen in this model may be pertinent to the study of clinical glaucomatous neuropathy.
Authors:
R L Radius
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  99     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-09-25     Completed Date:  1981-09-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1253-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aotus trivirgatus
Autoradiography
Axonal Transport*
Intraocular Pressure
Optic Nerve / pathology,  physiology*
Perfusion / instrumentation,  methods
Grant Support
ID/Acronym/Agency:
EY-01721/EY/NEI NIH HHS; EY-01931/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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