Document Detail


Distribution of preneoplastic lesions and tumors, and beta-catenin gene mutations in colon carcinomas induced by 1,2-dimethylhydrazine plus dextran sulfate sodium.
MedLine Citation:
PMID:  16761624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mucin-depleted foci (MDF) are considered as useful biomarkers in rat colon carcinogenesis. The purpose of the present study was to examine the mechanism(s) underlying rat colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) plus 1% Dextran Sulfate Sodium (DSS). Twelve male F344 rats were given subcutaneous injections (40mg/kg body) of DMH twice a week. They received DSS in the drinking water for 1 week after the first injection of DMH and then were maintained on tap water. The rats were sacrificed at 10 and 14 weeks after the first injection of DMH. Colon tissues were divided into 10 segments from anus to cecum (A/J) and stained with Alcian blue (AB) to identify MDF. We found that MDF and tumors were induced in the rat colon after treatment with DMH plus DSS and that the number of MDF in each segment of the colon was significantly correlated with that of tumors (p=0.006). In addition, we found that the beta-catenin protein was accumulated in cytoplasm and nuclei of MDF and the frequent beta-catenin gene mutations in the colon tumors. These results suggest that MDF is closely related to rat colon carcinogenesis induced by DMH plus DSS.
Authors:
T Kinjo; M Suzui; T Morioka; V Nabandith; M Inamine; T Kaneshiro; J Arakaki; T Nishimaki; N Yoshimi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of experimental & clinical cancer research : CR     Volume:  25     ISSN:  0392-9078     ISO Abbreviation:  J. Exp. Clin. Cancer Res.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-06-09     Completed Date:  2006-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308647     Medline TA:  J Exp Clin Cancer Res     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  89-95     Citation Subset:  IM    
Affiliation:
Tumor Pathology, Faculty of Medicine University of the Ryukyus, Okinawa, Japan. k038704@eve.u-ryukyu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
1,2-Dimethylhydrazine*
Animals
Carcinogens*
Colon / pathology
Colonic Neoplasms / chemically induced,  genetics*,  metabolism
Dextran Sulfate / pharmacology*
Dimethylhydrazines / metabolism
Humans
Male
Mutation*
Neoplasm Metastasis
Neoplasms, Experimental / genetics
Precancerous Conditions / genetics,  pathology*
Rats
Rats, Inbred F344
beta Catenin / genetics*
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Dimethylhydrazines; 0/beta Catenin; 540-73-8/1,2-Dimethylhydrazine; 9042-14-2/Dextran Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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