| Distribution of platinum in blood and perilymph in relation to cisplatin induced ototoxicity in the guinea pig. | |
| | |
MedLine Citation:
|
PMID: 18955125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cisplatin, a platinum-based chemotherapeutic drug, has severe dose-limiting side effects which include ototoxicity. In this study, we investigate the ototoxic effects of cisplatin in relation to the concentration of platinum in whole blood, plasma and perilymph. Guinea pigs were equipped with a permanent round window electrode for electrocochleography and treated with cisplatin on a daily basis (1.5mg/kg/day ip) until a 40dB shift of the compound action potential (CAP) threshold (3 microV isoresponse criterion) at 8kHz stimulation occurred. When this criterion was reached blood and perilymph was sampled and the total platinum concentration was measured. The number of days necessary to reach criterion threshold shift varied from 6 to 22. At this time, platinum concentration was found to be slightly more than 10 times higher in whole blood and plasma than in perilymph. While a significant correlation became apparent between threshold shift and total platinum concentration in whole blood and plasma, this was not the case for threshold shift and platinum concentration in perilymph. |
| | |
Authors:
|
Jan Willem Sepmeijer; Sjaak F L Klis |
Related Documents
:
|
6615055 - Hemodynamic differences between alcoholic and nonalcoholic cirrhotics following distal ... 4030175 - Ethanol disposition in man: comparison of breathalyzer and two methods of gas-liquid ch... 12771295 - Ultrasonographic diagnosis of parathyroid glands and percutaneous ethanol injection the... 12782555 - Day to day variability in the transferrin receptor/ferritin index in female athletes. 14702185 - Angiogenic factors and the endometrium following long term progestin only contraception. 4518355 - A bacteriological evaluation of laminar-flow systems for orthopaedic surgery. |
Publication Detail:
|
Type: Journal Article Date: 2008-10-14 |
Journal Detail:
|
Title: Hearing research Volume: 247 ISSN: 1878-5891 ISO Abbreviation: Hear. Res. Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2008-12-22 Completed Date: 2009-05-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7900445 Medline TA: Hear Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 34-9 Citation Subset: IM |
Affiliation:
|
Hearing Research Laboratories, Department of Otorhinolaryngology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Room G 02.531, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Action Potentials
/
drug effects,
physiology Animals Antineoplastic Agents / adverse effects*, pharmacology Auditory Threshold / drug effects, physiology Cisplatin / adverse effects*, pharmacology Cochlea / drug effects, innervation, physiopathology* Dose-Response Relationship, Drug Electrodes Guinea Pigs Hearing Loss / chemically induced*, metabolism* Male Models, Animal Perilymph / metabolism* Platinum / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 15663-27-1/Cisplatin; 7440-06-4/Platinum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Estimating the refractive index of pharmaceutical solids using predictive methods.
Next Document: Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising ...