Document Detail


Distribution patterns of vimentin-immunoreactive structures in the human prosencephalon during the second half of gestation.
MedLine Citation:
PMID:  10473296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuronal migration is guided by long radially oriented glial fibres. During late stages of development radial glial cells are transformed into astrocytes. A predominant intermediate filament protein within radial glial cells and immature astrocytes is vimentin. In this study fetal brain sections were used to demonstrate the transient features of vimentin-positive radial glia. In the lower half of the cerebral wall of the 6th gestational month bundles, curvature, and crossing of vimentin-positive fibres are regularly seen. Moreover, fibres terminating on vessels are observed. In the upper half fibres are radially oriented; when ascending towards the pial surface the number and diameter of fibres appears conspicuously decreased. Radially aligned fibres display numerous varicosities. In the 8th month the bulk of vimentin-positive fibres is encountered next to the ganglionic eminence and below isocortical cerebral fissures. The dentate gyrus is conspicuous due to its high amount of immunolabelled fibres. Furthermore, densely packed fibres are visible within the internal and external capsule and in the vicinity of the anterior commissure. Radial glial somata are found in the proliferative areas as well as in the adjacent white matter. In the latter location bipolar, monopolar and stellate vimentin-positive cells are present. The results demonstrate an area-specific distribution pattern of vimentin-positive structures which can be correlated with migrational events. Areas maturing late in development for instance, reveal dense immunolabelling in the 8th month. The orientation and position of radial fibres point to an additional developmental role of these fibres, i.e. their involvement in the guidance of growing axons. Moreover, the arrangement and morphology of vimentin-positive fibres, such as retraction of fibres or occurrence of varicosities, are indicative of degenerative events. Accordingly, a transformation of radial glial somata, their displacement towards the white matter and finally the growth of stellate processes can clearly be demonstrated.
Authors:
N Ulfig; F Neudörfer; J Bohl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of anatomy     Volume:  195 ( Pt 1)     ISSN:  0021-8782     ISO Abbreviation:  J. Anat.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-10-04     Completed Date:  1999-10-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0137162     Medline TA:  J Anat     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  87-100     Citation Subset:  IM    
Affiliation:
Department of Anatomy, University of Rostock, Germany.
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MeSH Terms
Descriptor/Qualifier:
Astrocytes / physiology*
Axonal Transport
Embryonic and Fetal Development / physiology*
Female
Humans
Immunohistochemistry
Neuroglia / physiology*
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prosencephalon / chemistry*,  embryology*
Vimentin / analysis*
Chemical
Reg. No./Substance:
0/Vimentin
Comments/Corrections

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