Document Detail

Distribution, ontogeny and ultrastructure of the mammalian secretin cell.
MedLine Citation:
PMID:  328159     Owner:  NLM     Status:  MEDLINE    
Immunocytochemically, secretin cells have been demonstrated to occur in the duodenum and jejunum of several mammals. Calculations on the relative frequency of such cells indicate that the bulk of secretin occurs in the jejunum, a fact supporting the view that secretin may be released by physiological stimulants other than hydrochloric acid. Electron microscopical identification of cat and pig secretin cells confirmed their identity with the ultrastructurally defined S cells, and staining experiments revealed that secretin cells were argyrophilic both with the method of Grimelius and with that of Hellerström and Hellman. Secretin cells are detected already in the 17-day old fetal rat duodenum and show a developmental pattern similar to that displayed by the gastrin cells. It is suggested that secretin may play a role in the early regulation of growth of the fetal gastrointestinal tract.
L I Larsson; F Sundler; J Alumets; R Håkanson; O B Schaffalitzky de Muckadell; J Fahrenkrug
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell and tissue research     Volume:  181     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-09-29     Completed Date:  1977-09-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  361-8     Citation Subset:  IM    
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MeSH Terms
Duodenum / cytology
Fluorescent Antibody Technique
Intestinal Mucosa / ultrastructure
Intestine, Small / cytology*
Jejunum / cytology
Microscopy, Electron
Secretin / secretion*
Reg. No./Substance:

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