Document Detail


Distribution of oncofetal fibronectin in human mammary tumors: immunofluorescence study on histological sections.
MedLine Citation:
PMID:  2406016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two types of human fibronectin have been detected by the reactivity of specific monoclonal antibody FDC-6: (a) those present in normal plasma and adult tissues, which do not react with FDC-6 (normal fibronectin or norFN); and (b) those present in fetal tissues and in tumoral cell lines, which do react with FDC-6 (oncofetal fibronectin or onfFN) (H. Matsuura and S. I. Hakomori, Proc. Natl. Acad. Sci. USA, 82: 6517-6521, 1985). We compared the distribution of norFN and onfFN in normal breast tissue (15 samples), breast fibroadenoma (ten samples), and breast adenocarcinoma (80 samples), using an immunofluorescence technique with monoclonal antibody FDC-6. A polyclonal antiserum against human normal fibronectin was used as a control. While norFN was diffusely present in normal gland and in benign and malignant tumors, onfFN was absent in normal gland and in benign tumors. In carcinomas, however, its presence was frequent, as we found it in 60% of cases. Among classical prognosis factors in breast carcinomas, onfFN distribution was significantly correlated with histological grade. Indeed, the presence of FDC-6 labeling was significantly linked with intermediary and high malignancy grades, while its absence was significantly linked with low malignancy grade. onfFN could be considered a marker of the neoplastic state; its immunohistological detection may represent a new prognosis factor in breast carcinomas.
Authors:
B Loridon-Rosa; P Vielh; H Matsuura; H Clausen; C Cuadrado; P Burtin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  50     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-03-21     Completed Date:  1990-03-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1608-12     Citation Subset:  IM    
Affiliation:
Laboratoire d'Anatomie Pathologique, CNRS, Villejuif, France.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / analysis*
Base Sequence
Breast / analysis*
Breast Neoplasms / analysis*
Fibrocystic Breast Disease / analysis*
Fibronectins / analysis*
Fluorescent Antibody Technique
Humans
Molecular Sequence Data
Grant Support
ID/Acronym/Agency:
CA42505/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Fibronectins

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