Document Detail

Distribution of neuropeptides in synovium of the knee with osteoarthritis.
MedLine Citation:
PMID:  10906873     Owner:  NLM     Status:  MEDLINE    
Synovial tissue was obtained from medial, lateral, and suprapatellar sites of 21 knees (15 patients) with medial compartmental osteoarthritis at surgery. All patients reported pain around the medial joint of their knees while walking and climbing stairs. For investigation of the synovial innervation, six samples were stained with modified gold chloride and the others with an immunohistochemical method using antisera against neuropeptides. The extent of synovitis in each part was scored using a new 10-point scale. The results showed that the synovium had an extensive neural network in the somatic and autonomic nervous systems. Neuropeptides were most abundant, with an especially large number of substance P and calcitonin gene related peptide immunoreactive free nerve endings. Some of the substance P positive nerve endings were surrounded by monocytes. Substance P and calcitonin gene related peptide were found more frequently in the medial than in the lateral or suprapatellar areas. Substance P positive free nerve endings showed more dendritic morphologic features in the medial region than did those in the lateral and suprapatellar regions, and small nerves were accompanied by newly developed vessels in synovial villi. In the medial region, the synovitis was more remarkable than in the lateral region. These findings suggest that free nerve endings containing substance P may modulate inflammation and the pain pathway in osteoarthritis.
T Saito; T Koshino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-02     Completed Date:  2000-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  172-82     Citation Subset:  AIM; IM    
Department of Orthopaedic Surgery, Yokohama City University School of Medicine, Japan.
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MeSH Terms
Calcitonin Gene-Related Peptide / metabolism
Middle Aged
Neuropeptide Y / metabolism
Neuropeptides / analysis*
Osteoarthritis, Knee / metabolism*
Substance P / metabolism
Synovial Membrane / metabolism*
Reg. No./Substance:
0/Neuropeptide Y; 0/Neuropeptides; 33507-63-0/Substance P; 83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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