| Distribution and neuropeptide content of nitric oxide synthase-containing nerve fibers in arteries and conduction system of the rat heart. | |
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MedLine Citation:
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PMID: 9732124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rat heart receives its blood supply not only from the coronary arteries but also from the accessory coronary arteries that supply mainly the atria. The distribution and chemical nature of nitric oxide synthase-containing nerve fibers in the conduction system as well as the coronary and accessory coronary arteries were investigated using immunohistochemistry and NADPH diaphorase (NADPH-d) histochemistry. A few NADPH-d-positive nerve fibers were observed mainly around the main trunk of the coronary arteries, while NADPH-d-positive fibers were found along the entire course of the accessory coronary arteries from their main branches to the arteriolar level. A double-staining method demonstrated that NADPH-d-positive fibers innervating both the coronary and accessory coronary arteries contained vasoactive intestinal polypeptide or neuropeptide Y. NADPH-d-positive fibers were relatively abundant in the sinus node and penetrating bundle but were very sparse in the atrioventricular node and right bundle branch. No NADPH-d-positive fibers were detected in the left bundle branch. Some of the NADPH-d-positive fibers innervating the penetrating bundle exhibited distinct immunoreactivity to calcitonin gene-related peptide. These results suggest that nitric oxide may play a role as a neurotransmitter and/or neuromodulator in the neural control of the cardiac blood flow and impulse conduction. |
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Authors:
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K Sawada; T Kondo; J Chang; T Inokuchi; S Aoyagi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta anatomica Volume: 160 ISSN: 0001-5180 ISO Abbreviation: Acta Anat (Basel) Publication Date: 1997 |
Date Detail:
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Created Date: 1998-09-30 Completed Date: 1998-09-30 Revised Date: 2007-07-02 |
Medline Journal Info:
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Nlm Unique ID: 0370272 Medline TA: Acta Anat (Basel) Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 239-47 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Kurume University School of Medicine, Kurume, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcitonin Gene-Related Peptide / metabolism Coronary Vessels / innervation* Fluorescent Antibody Technique, Indirect Heart Conduction System / enzymology* Immunoenzyme Techniques Male NADPH Dehydrogenase / metabolism Nerve Fibers / enzymology* Neuropeptide Y / metabolism Neuropeptides / metabolism* Nitric Oxide / physiology Nitric Oxide Synthase / metabolism* Nitric Oxide Synthase Type I Rats Rats, Wistar Vasoactive Intestinal Peptide / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 0/Neuropeptides; 10102-43-9/Nitric Oxide; 37221-79-7/Vasoactive Intestinal Peptide; 83652-28-2/Calcitonin Gene-Related Peptide; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type I; EC 1.14.13.39/Nos1 protein, rat; EC 1.6.99.1/NADPH Dehydrogenase |
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