Document Detail


Distribution of neuroendocrine cells in the small and large intestines of the one-humped camel (Camelus dromedarius).
MedLine Citation:
PMID:  17688943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution and relative frequency of neuroendocrine cells in the small and large intestines of one-humped camel were studied using antisera against 5-hydroxytryptamine (5-HT), cholecystokinin (CCK-8), somatostatin (SOM), peptide tyrosine tyrosine (PYY), gastric inhibitory polypeptide (GIP), neuronal nitric oxide synthase (nNOS), gastrin releasing peptide (GRP), substance P (SP), and neurokinin A (NKA). Among these cell types, CCK-8 immunoreactive (IR) cells were uniformly distributed in the mucosa, while others showed varied distribution in the villi or crypts of the small intestine. Immunoreactive cells like 5HT, CCK-8, and SOM showed peak density in the villi and crypts of the small intestine and in the colonic glands of the large intestine, while cells containing SP were discerned predominately in the crypts. 5-HT, CCK-8 and SOM cells were mainly flask-shaped and of the open-variety, while PYY and SP immunoreactive cells were mainly rounded or basket-shaped and of the closed variety. Basically the distribution pattern of the endocrine cells in the duodenum, jejunum and colon of the one-humped camel is similar to that of other mammals. Finally, the distribution of these bioactive agents may give clues as to how these agents aid in the function of the intestinal tract of this desert animal.
Authors:
M Al Haj Ali; Fred Nyberg; S I Chandranath; S Dhanasekaran; Saeed Tariq; G Petroianu; M Y Hasan; Ernest A Adeghate; A Adem
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-03
Journal Detail:
Title:  Neuropeptides     Volume:  41     ISSN:  0143-4179     ISO Abbreviation:  Neuropeptides     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-20     Completed Date:  2007-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  293-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates. mahmoud_alhaj@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Camels
Cholecystokinin / analysis
Gastric Inhibitory Polypeptide / analysis
Gastrin-Releasing Peptide / analysis
Immunohistochemistry
Intestine, Large / cytology,  physiology*
Intestine, Small / cytology,  physiology*
Neurokinin A / analysis
Nitric Oxide Synthase Type III / analysis
Serotonin / analysis*
Sincalide / analysis
Somatostatin / analysis
Substance P / analysis
Chemical
Reg. No./Substance:
25126-32-3/Sincalide; 33507-63-0/Substance P; 50-67-9/Serotonin; 51110-01-1/Somatostatin; 59392-49-3/Gastric Inhibitory Polypeptide; 80043-53-4/Gastrin-Releasing Peptide; 86933-74-6/Neurokinin A; 9011-97-6/Cholecystokinin; EC 1.14.13.39/Nitric Oxide Synthase Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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