Document Detail

Distribution and mixing of a liquid bolus in pleural space.
MedLine Citation:
PMID:  15955748     Owner:  NLM     Status:  MEDLINE    
Distribution and mixing time of boluses with labeled albumin in pleural space of anesthetized, supine rabbits were determined by sampling pleural liquid at different times in various intercostal spaces (ics), and in cranial and caudal mediastinum. During sampling, lung and chest wall were kept apposed by lung inflation. This was not necessary in costo-phrenic sinus. Here, 10 min after injection, lung inflation increased concentration of labeled albumin by 50%. Lung inflation probably displaces some pleural liquid cranio-caudally, increasing labeled albumin concentration caudally to injection point (6th ics), and decreasing it cranially. Boluses of 0.1-1 ml did not preferentially reach mediastinal regions, as maintained by others. Time for an approximate mixing was approximately 1 h for 0.1 ml, and approximately 30 min for 1 ml. This relatively long mixing time does not substantially affect determination of contribution of lymphatic drainage through stomata to overall removal of labeled albumin from 0.3 ml hydrothoraces lasting 3 h [Bodega, F., Agostoni, E., 2004. Contribution of lymphatic drainage through stomata to albumin removal from pleural space. Respir. Physiol. Neurobiol. 142, 251-263].
Francesca Bodega; Claudio Tresoldi; Cristina Porta; Luciano Zocchi; Emilio Agostoni
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-06-13
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  150     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-14     Completed Date:  2006-05-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  287-99     Citation Subset:  IM    
Istituto di Fisiologia Umana I, Università di Milano, Via Mangiagalli 32, I-20133 Milano, Italy.
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MeSH Terms
Albumins / metabolism*
Body Fluids / physiology*
Capillary Permeability
Pleura / cytology
Pleural Cavity / metabolism*
Pleural Effusion
Supine Position / physiology
Time Factors
Tissue Distribution
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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