| Distribution of micafungin in the tissue fluids of patients with invasive fungal infections. | |
| | |
MedLine Citation:
|
PMID: 21537970 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The distribution of micafungin (MCFG) in tissue fluids, such as cerebrospinal fluid (CSF), pleural effusions, ascites, and wound tissue fluids, was examined in seven patients with invasive fungal infections. MCFG (100-300 mg) was administered once daily over a 1-h intravenous infusion. Blood and tissue fluid samples were collected from 1 to 24 h after infusion. Although two patients had similar MCFG concentrations in their plasma, the concentrations in the CSF differed between these two patients. The concentration in the CSF of one patient was much higher than the MIC(90) for Candida albicans, Candida glabrata, and Aspergillus fumigatus, whereas the MCFG concentration in the CSF of the other patient was comparable to the MIC(90). By contrast, MCFG concentrations in pleural effusions, ascites, and wound tissue fluids were above the MIC(90) . These results suggest that intravenous MCFG may be effective to treat invasive fungal infections that invade the organs and tissues. |
| | |
Authors:
|
Noriaki Yamada; Keisuke Kumada; Satoshi Kishino; Nobuo Mochizuki; Keiko Ohno; Shinji Ogura |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-3 |
Journal Detail:
|
Title: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Volume: - ISSN: 1437-7780 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9608375 Medline TA: J Infect Chemother Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Disaster and Emergency Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Readiness-to-Change Cluster Profiles Among Adults with Mental Illness Who were Homeless Participatin...
Next Document: Development of a miniaturized mass-flow meter for an axial flow blood pump based on computational an...