Document Detail

Distribution and metabolism of selenohomolanthionine labeled with a stable isotope.
MedLine Citation:
PMID:  20820996     Owner:  NLM     Status:  In-Data-Review    
The distribution and metabolism of selenohomolanthionine (4,4'-selenobis[2-aminobutanoic acid], SeHLan), a newly identified selenoamino acid in selenized Japanese pungent radish, were evaluated by administering (77)Se-labeled SeHLan at a dose of 25 μg/kg body weight in rats. Exogenous (77)Se of SeHLan was preferably distributed to the kidneys and remained in the intact form for up to 6 h after dosing. The accumulation in the kidneys is one of the specific characteristics of SeHLan, differing from other selenoamino acids, such as selenomethionine and Se-methylselenocysteine, which preferably accumulate in the pancreas. The intact form of SeHLan was detected in the serum and kidney supernatant but not in the urine, suggesting that the amount of exogenous Se that was distributed to the kidneys was within metabolic capacity. Indeed, the exogenous Se was converted into two urinary metabolites, Se-methylseleno-N-acetyl-galactosamine and trimethylselenonium. Exogenous Se was also detected in several selenoproteins, including selenoprotein P and extracellular glutathione peroxidase. SeHLan is expected to be a potential supplemental source of Se because its distribution differs from that of selenomethionine and Se-methylselenocysteine.
Yasumi Anan; Takahiro Mikami; Yoshiro Tsuji; Yasumitsu Ogra
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Publication Detail:
Type:  Journal Article     Date:  2010-09-06
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  399     ISSN:  1618-2650     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1765-72     Citation Subset:  IM    
Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
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