| Distribution of mercury and evaluation of testicular steroidogenesis in mercuric chloride and methylmercury administered rats. | |
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MedLine Citation:
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PMID: 2253967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intraperitoneal administration of methylmercury chloride (MMC) and mercuric chloride (MC) to male rats in doses of 5, 10 micrograms MMC/kg or 50, 100 micrograms MC/kg for 90 days induced cellular disintegration of Leydig cells which was conspicuous on day 30 and onwards in the exposed groups. Progressive degeneration of Leydig cells and decrease in their nuclear diameter and population were associated with gradual increase in deposition of mercury. Gradual diminution of 3 beta-hydroxy-delta 5-steroid dehydrogenase activity in Leydig cells after MMC or MC treatment was correlated with different structural deformations of the cells over 90 days. Moreover, a significant decrease in serum testosterone levels by day 90 confirmed steroidogenic impairment after MMC or MC treatment. |
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Authors:
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K D Vachhrajani; A R Chowdhury |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Indian journal of experimental biology Volume: 28 ISSN: 0019-5189 ISO Abbreviation: Indian J. Exp. Biol. Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1991-01-22 Completed Date: 1991-01-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0233411 Medline TA: Indian J Exp Biol Country: INDIA |
Other Details:
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Languages: eng Pagination: 746-51 Citation Subset: IM |
Affiliation:
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National Institute of Occupational Health, Meghani Nagar, Ahmedabad, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxysteroid Dehydrogenases
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analysis Animals Cell Nucleus / drug effects, ultrastructure Leydig Cells / drug effects, secretion, ultrastructure Male Mercuric Chloride / administration & dosage, pharmacology* Methylmercury Compounds / administration & dosage, pharmacology* Rats Testis / drug effects*, secretion Testosterone / secretion* |
| Chemical | |
Reg. No./Substance:
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0/Methylmercury Compounds; 115-09-3/methylmercuric chloride; 58-22-0/Testosterone; 7487-94-7/Mercuric Chloride; EC 1.1.-/3-Hydroxysteroid Dehydrogenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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