| Distribution of macrovascular disease in scleroderma. | |
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MedLine Citation:
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PMID: 9797553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Macrovascular disease in scleroderma has recently been described in two comparative studies. The aim of this study was to map its anatomical distribution. METHODS: In a retrospective cohort study of 20 scleroderma patients, the results of Doppler studies of arteries in the limbs, neck, and abdomen were compared with those from 20 cohort negative patients. The latter were matched for age, sex, and the presence/absence of hypertension, hyperlipidaemia, smoking, and diabetes status. Arteries were compared quantitatively using a body surface area adjusted measurement of intraluminal diameter, and qualitatively using descriptive characteristics of the arterial walls. The latter were binomially categorised under three non-exclusive headings--thickening, stenosis, and calcification. RESULTS: The ulnar arteries in scleroderma patients were significantly narrower than those of the negative cohort. The arterial walls were also characterised by smooth thickening along their entire length. The characteristics of the other arteries, including those of the lower limbs, were not significantly different from those of the negative cohort. CONCLUSION: The ulnar artery seems to be specifically targeted in patients with scleroderma. Assessment of the ulnar artery should be considered in these patients by means of a modified Allen's test or Doppler sonography especially in the presence of digital gangrene. |
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Authors:
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L Stafford; H Englert; J Gover; J Bertouch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 57 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-11-05 Completed Date: 1998-11-05 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 476-9 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, Prince Henry Hospital, Sydney, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amputation Antibodies, Anticardiolipin / blood Arterial Occlusive Diseases / etiology, pathology Cohort Studies Female Humans Leg / surgery Male Middle Aged Peripheral Vascular Diseases / etiology* Retrospective Studies Risk Factors Scleroderma, Systemic / complications*, immunology Ulnar Artery / pathology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anticardiolipin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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