| Distribution of lymphoid cells in tonsillar compartments in relation to infection and age. A quantitative study using image analysis. | |
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MedLine Citation:
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PMID: 1374208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution of lymphoid cells in the mantle zone, germinal center, interfollicular area, and subepithelial area of the tonsil was evaluated quantitatively by image analysis in 66 subjects aged 3 to 66 years. The number of Ig-positive cells in the tonsil decreased with advancing years in all compartments. This inverse correlation to age was statistically significant for IgD-, IgM-, and IgG-positive cells. For T-cells, overall change of each T-cell subset with age was smaller than those of Ig-positive cells. An age-related marked decline was seen for CD4-positive cells only in the subepithelial area and for CD8-positive cells only in the interfollicular area. Ki-67-positive cells, cells undergoing active division, were mainly found in the germinal centers and also diminished with advancing years. Patients with frequent episodes of tonsillitis demonstrated a significant increase of IgD-positive cells and IgG-positive cells in interfollicular and subepithelial compartments and a decrease of CD4-positive T-cells in the germinal centers and subepithelial areas. These results suggest that the tonsillar involution with age is immunologically associated in all compartments with the decrease of Ig-positive cells and Ki-67-positive activated cells resulting in a relative increase of T-cell subsets. The method of image analysis provides a novel and unique approach for quantitative immunohistological study of the tonsil. |
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Authors:
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N Yamanaka; H Matsuyama; Y Harabuchi; A Kataura |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta oto-laryngologica Volume: 112 ISSN: 0001-6489 ISO Abbreviation: Acta Otolaryngol. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-06-02 Completed Date: 1992-06-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 128-37 Citation Subset: IM; X |
Affiliation:
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Department of Otolaryngology, Sapporo Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged B-Lymphocytes / cytology, immunology, pathology CD4-CD8 Ratio Child Child, Preschool Humans Hypertrophy / immunology, pathology Image Processing, Computer-Assisted / methods Immunoglobulins / analysis Leukocyte Count Lymphocytes / cytology*, immunology, pathology Middle Aged Palatine Tonsil / cytology*, immunology, pathology Staining and Labeling / methods T-Lymphocytes / cytology, immunology, pathology Tonsillitis / immunology, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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