| Distribution and localization of cells and collagens in the proliferated intima of arterially implanted autovein grafts. | |
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MedLine Citation:
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PMID: 10452239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the microscopic features and distribution of collagens in the hyperplastic intima of arterially implanted autovein bypass grafts under conditions of a reduced blood flow with a poor distal outflow. Vascular anastomosis was made using 7-0 nonabsorbable polypropylene sutures (PP group), or absorbable polydioxanone sutures (PDS group). On the contralateral limb, an autovein bypass graft was performed under normal flow conditions (NF group). The thickness of the intima in the NF group was approximately 50 microm throughout the duration of the study, while in the PP and PDS groups, intimal hyperplasia progressed to 290+/-112 microm and 267+/-123 microm, respectively, at 13 months after grafting. Collagen accumulated significantly in both the PP and PDS groups; types IV and V collagen in particular increased considerably in the deep layer. Regardless of the suture materials, the progression of intimal hyperplasia was considered to be closely related to the poor distal outflow to be and caused by the proliferation of myofibroblasts and active production of collagen. The increase in types IV and V collagen, particularly in the deep layer of the hyperplastic intima, was due to development of numerous vasa vasora in this region. |
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Authors:
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M Tamaki; M Tamashiro; Y Kamada; K Koja; A Kusaba |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgery today Volume: 29 ISSN: 0941-1291 ISO Abbreviation: Surg. Today Publication Date: 1999 |
Date Detail:
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Created Date: 1999-09-29 Completed Date: 1999-09-29 Revised Date: 2006-08-03 |
Medline Journal Info:
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Nlm Unique ID: 9204360 Medline TA: Surg Today Country: JAPAN |
Other Details:
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Languages: eng Pagination: 614-25 Citation Subset: IM |
Affiliation:
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Second Department of Surgery, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Surgical Animals Collagen / analysis*, pharmacology Dogs Female Femoral Artery / surgery* Femoral Vein / transplantation* Graft Occlusion, Vascular / physiopathology* Hyperplasia Male Postoperative Complications Sutures Transplantation, Autologous Tunica Intima / chemistry, pathology Vascular Patency |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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