| Distribution of local anesthetics: accumulation in some endocrine polypeptide-hormone producing cell systems. | |
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MedLine Citation:
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PMID: 4458846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1 After the injection of labelled procaine and lidocaine in mice, the location and concentration of radioactivity was demonstrated by autoradiographical methods.2 An accumulation in some endocrine cells such as the pancreatic islets, the hypophysis, the adrenal medulla and certain cells of the thyroid (probably representing the calcitonin-producing parafollicular cells) was shown.3 After the injection of [(14)C]-procaine in chicks, an accumulation of radioactivity was observed in the ultimobranchial gland (which produces calcitonin in birds), but not in the thyroid.4 Radioactivity was also shown to be strongly concentrated in structures containing melanin, such as the pigment of the eye, skin and hair and in some organs involved in the metabolism and excretion of these drugs. |
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Authors:
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L Hammarström; P Slanina; H Tjälve; S Ullberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 52 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1974 Nov |
Date Detail:
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Created Date: 1975-07-28 Completed Date: 1975-07-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 367-74 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Local
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metabolism* Animals Autoradiography Chickens Endocrine Glands / metabolism* Hormones / biosynthesis* Lidocaine / metabolism Male Mice Mice, Inbred CBA Mice, Inbred Strains Peptide Biosynthesis* Procaine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Hormones; 137-58-6/Lidocaine; 59-46-1/Procaine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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