Document Detail

Distribution of lead in human milk fractions: relationship with essential minerals and maternal blood lead.
MedLine Citation:
PMID:  15621925     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine the concentration and distribution of lead, calcium, iron, zinc, and copper in major fractions (fat, casein, whey) of mature milk from 38 nursing adult women with low environmental lead exposure. The potential associations between milk lead and maternal blood lead and between milk and blood lead and essential mineral data (nutritional status, dietary intake, and milk concentration) were investigated. Maternal blood lead (geometric mean, 60 microg/L) was negatively associated, although modestly, with dietary calcium intake (r=-0.32, p=0.02). Lead in whole milk (geometric mean, 1.2 microg/L) was positively associated with calcium in whole milk (r=0.56, p=0.005). Distribution of lead in milk fractions was 63%, 28%, and 9%, in whey, fat, and casein, respectively. Milk distribution of essential minerals was 67-76%, 17-18%, and 7-17% in whey, fat, and casein, respectively. Lead in milk whey was positively associated with lead in maternal blood (r=0.49, p=0.02). However, milk lead was not affected by nutritional status, dietary intake, and milk composition of the essential minerals. The high percentage of lead in the milk whey fraction, as seen for the essential minerals, suggests that most lead in human milk is bioavailable to the infant.
Alexandra da Silva Anastácio; Carmem Lucia Porto da Silveira; Norbert Miekeley; Carmen Marino Donangelo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  102     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2004  
Date Detail:
Created Date:  2004-12-28     Completed Date:  2005-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  27-37     Citation Subset:  IM    
Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, CT, Bloco A, 528, 21949-900 Rio de Janeiro, Brazil.
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MeSH Terms
Biological Availability
Calcium / analysis
Calcium, Dietary / administration & dosage
Caseins / analysis
Copper / analysis
Glycolipids / analysis
Glycoproteins / analysis
Iron / analysis
Lead / analysis*,  blood
Milk Proteins / analysis
Milk, Human / chemistry*
Nutritional Status
Zinc / analysis
Reg. No./Substance:
0/Calcium, Dietary; 0/Caseins; 0/Glycolipids; 0/Glycoproteins; 0/Milk Proteins; 0/milk fat globule; 0/whey protein; 7439-89-6/Iron; 7439-92-1/Lead; 7440-50-8/Copper; 7440-66-6/Zinc; 7440-70-2/Calcium

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