| Distribution of intrachromosomal telomeric sequences (ITS) on Macaca fascicularis (Primates) chromosomes and their implication for chromosome evolution. | |
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MedLine Citation:
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PMID: 12107444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intrachromosomal location of the telomeric sequence in the crab-eating macaque, Macaca fascicularis (F. Cercopithecidae, Catarrhini) has been analysed by fluorescent in situ hybridisation with a long synthetic (TTAGGG)(n) probe. A total of 237 metaphases was analysed. As expected, all telomeres hybridised with the probe and 90 intrachromosomal loci with different hybridisation frequencies were also detected. The chromosomal location of interstitial telomeric sequences in M. fascicularis and in Homo sapiens was then compared, 37 sites (41.11%) being found to be conserved. Some of these sequences can be derived from rearrangements, such as inversions (MFA13q23) or fusions (MFA2p13 and MFA13p12), that have taken place during karyotype evolution. |
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Authors:
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A Ruiz-Herrera; F García; C Azzalin; E Giulotto; J Egozcue; M Ponsà; M Garcia |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2002-05-04 |
Journal Detail:
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Title: Human genetics Volume: 110 ISSN: 0340-6717 ISO Abbreviation: Hum. Genet. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-07-10 Completed Date: 2002-08-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7613873 Medline TA: Hum Genet Country: Germany |
Other Details:
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Languages: eng Pagination: 578-86 Citation Subset: IM |
Affiliation:
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Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Chromosome Fragility / genetics Evolution, Molecular* Female Humans In Situ Hybridization, Fluorescence Karyotyping Macaca fascicularis / genetics* Species Specificity Tandem Repeat Sequences Telomere / genetics* |
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