Document Detail


Distribution of interleukin-1 receptor antagonist genotypes in sudden unexpected death in infancy (SUDI); unexplained SUDI have a higher frequency of allele 2.
MedLine Citation:
PMID:  20092400     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: This investigation was designed to explore the role of IL-1RN genotype in unexplained infant deaths (including sudden infant death syndrome (SIDS)), non-infectious infant deaths, and infectious infant deaths, and to investigate whether IL-1RN genotype is related to the finding of organisms in normally sterile sites in infant deaths. METHODS: IL-1RN 89bp variable number of tandem repeat polymorphism genotype was determined using polymerase chain reaction for 49 cases of unexplained sudden unexpected death in infancy (uSUDI), 13 cases of infectious sudden unexpected death in infancy, 10 cases of non-infectious sudden unexpected death in infancy, and 103 live control infants. IL-1RN genotype was then compared with the presence of bacteria in normally sterile sites in infant deaths. RESULTS: An association was found between the homozygous A2 allele and uSUDI (P = 0.007; 95% confidence interval 1.41-17.67) where carriage of the 2/2 genotype was 4.85 times more likely to increase risk of uSUDI compared with the predominant 1/1 genotype. CONCLUSIONS: The role of infection in uSUDI and SIDS may be via an immune response pathway where IL-1RN A2 affects interleukin (IL)-1 regulation. These results are consistent with previous research where polymorphic genotypes conferring more severe proinflammatory responses are found more frequently in uSUDI/SIDS infants than in controls.
Authors:
Amanda R Highet; Anne M Berry; Paul N Goldwater
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of medicine     Volume:  42     ISSN:  1365-2060     ISO Abbreviation:  Ann. Med.     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  64-9     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Infectious Diseases, SA Pathology at the Women's & Children's Hospital, 72 King William Road, North Adelaide, South Australia, Australia. amanda.highet@adelaide.edu.au
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MeSH Terms
Descriptor/Qualifier:
Australia
Female
Gene Frequency
Genotype
Humans
Infant
Infant, Newborn
Interleukin 1 Receptor Antagonist Protein / genetics*
Male
Polymorphism, Genetic
Staphylococcal Infections / complications*,  immunology
Staphylococcus aureus*
Sudden Infant Death / genetics*,  immunology
Tandem Repeat Sequences / genetics
Chemical
Reg. No./Substance:
0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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