| Distribution of human papillomavirus among women with abnormal cervical cytology in Kuwait. | |
| | |
MedLine Citation:
|
PMID: 21987449 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
This study investigates the distribution of human papillomavirus (HPV) in women with abnormal cervical cytology in Kuwait. Two hundred and ninety-eight (298) abnormal ThinPreps were taken from women seeking routine gynecological care and screened for HPV DNA by real-time PCR. HPV genotyping was determined by PCR-based sequencing. HPV DNA was detected in 152 women (51%), and 29 different HPV genotypes were detected, comprising 16 high-risk (HR) (16, 18, 31, 33, 35, 39, 45, 51, 53, 56, 58, 59, 66, 68, 73, 97), nine low-risk (LR) (6, 11, 54, 61, 74, 81, 90, 102, 106), and four intermediate-risk (IR) (62, 67, 84, 87). HPV16 had the highest prevalence (24.3%), followed by HPV11 (13.8%), HPV66 (11.2%), HPV33 (9.9%), HPV53 (9.2%), HPV81 (9.2%), HPV56 (7.9%) and HPV18 (6.6%). HPV prevalence was 86, 67, and 89% in women with invasive cervical carcinoma (ICC), high-grade squamous intraepithelial lesion (HSIL) and low-grade squamous intraepithelial lesion (LSIL), respectively. As for age distribution, 69% of all HPVs were found in women aged 20-29 years, and the HPV incidence rate deceased with increasing age. The proportion of single infections decreased as the severity of the cytological diagnosis increased, while the proportion of multiple infections increased. This study is the first of its type in Kuwait and one of few in the Middle East. The findings are consistent with the hypothesis that HPV infection is the primary cause of cervical neoplasia. They support HPV vaccine research to prevent cervical cancer and efforts to develop HPV DNA diagnostic tests. Diagn. Cytopathol. 2011;. © 2011 Wiley-Liss, Inc. |
| | |
Authors:
|
Rana Al-Awadhi; Wassim Chehadeh; Mohammad Jaragh; Azza Al-Shaheen; Prem Sharma; Kusum Kapila |
Related Documents
:
|
21939419 - Bacterial contamination of platelet components: potential solutions to prevent transfus... 12650679 - Hormonal aspects of schizophrenias: an overview. 8242269 - The xy female in sport: the controversy continues. 16760619 - The hormonal pathway to frailty in older men. 9493489 - Female hypoactive sexual desire disorder due to androgen deficiency: clinical and psych... 9595019 - Structuring a safer donor-replacement program. 10063429 - Relationship between serum c3 levels and traditional risk factors for myocardial infarc... 1589669 - Factors provoking lower urinary tract infection in women. 20598979 - The impact of combined health factors on cardiovascular disease mortality. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-11 |
Journal Detail:
|
Title: Diagnostic cytopathology Volume: - ISSN: 1097-0339 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8506895 Medline TA: Diagn Cytopathol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
|
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Sulaibikhat 90805, Kuwait. r.al-awadhi@hsc.edu.kw. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: T-cell lymphoblastic lymphoma shows differences and similarities with T-cell acute lymphoblastic leu...
Next Document: Clinical epidemiology of Crohn's disease in Arabs based on the Montreal classification.