| Distribution of hemoglobin phenotypes in four different districts of Porto Velho, Rondônia, Brazil. | |
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MedLine Citation:
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PMID: 19341324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemoglobin profile studies have been carried out in four samples from different districts of Porto Velho (Rondônia State) in the western Amazonian region of Brazil: Candelária, Bate Estaca, Hemeron (at the State Blood Bank), and São Carlos. Samples from 337 unrelated individuals were collected during medical and paramedical team visits by professionals from the Instituto de Pesquisa em Patologia Tropical and the Centro de Pesquisa em Patologias Tropicais (both research institutes in tropical diseases). The aim of this study is to assess the frequency of alleles in the hemoglobin system, mainly alleles HB*A, *S, and *E. The overall phenotype frequencies were HB A,S = 0.025, HB A,E = 0.006, and HB A,A = 0.969. Samples from the blood bank subjects and samples from the homogeneous areas of São Carlos and Candelária plus Bate Estaca have a chi-square of heterogeneity of 6.383 (p = 0.041) and 8.406 (p = 0.015), respectively. The allele frequencies (HB*A = 0.984, HB*S = 0.012, and HB*E = 0.003) do not significantly differ from frequencies found in other Brazilian regions. |
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Authors:
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A Andrade-Casseb; A Krauze; R M Lafontaine; M S Tada; W A Silva; A L Simões; V Engracia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human biology Volume: 80 ISSN: 0018-7143 ISO Abbreviation: Hum. Biol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2009-04-03 Completed Date: 2009-06-18 Revised Date: 2011-04-18 |
Medline Journal Info:
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Nlm Unique ID: 0116717 Medline TA: Hum Biol Country: United States |
Other Details:
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Languages: eng Pagination: 573-9 Citation Subset: IM |
Affiliation:
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Instituto de Pesquisa em Patologia Tropical (IPERATRO), BR 364, Km 3.5, 78900-970 Porto Velho, RO, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group
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genetics Animals Brazil Emigration and Immigration European Continental Ancestry Group / genetics Gene Flow / genetics Gene Frequency* Genetic Drift Genetics, Population / statistics & numerical data* Hemoglobin A / genetics* Hemoglobin E / genetics* Hemoglobin, Sickle / genetics* Humans Indians, South American / genetics Likelihood Functions Malaria / blood, genetics, prevention & control Phenotype Plasmodium / genetics Polymorphism, Genetic / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin, Sickle; 9034-51-9/Hemoglobin A; 9034-61-1/Hemoglobin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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