| Distribution of heavy chain classes and light chain types in 757 cases of monoclonal gammapathies. | |
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MedLine Citation:
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PMID: 821548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution in heavy chain classes and light chain types of M components were studied in 757 cases of monoclonal gammapathies. These gammapathies were classified according to clinical and hematological data in 439 myeloma (MM), 165 Waldenström's macroglobulinemia (WM) and 152 monoclonal gammapathies occurring in other conditions. The IgG/IgA ratio differs in myeloma and in non-myelomatous gammapathies (64% IgG versus 33% IgA in myeloma and 95% IgG versus 5% in absence of myeloma). Presence of free light chains in patient's urines (Bence Jones proteinuria) was detected in about 72% of cases of MM, 48% of WM and only in 9% in others gammapathies. Concerning the sex of patients, an equal repartition between males and females is observed in MM, whereas males predominate in WM. The age distribution of the patients shows that 74% of myeloma and 79% of WM were above sixty. In addition to the 757 cases under study, 10 sera with two M Components were characterized. |
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Authors:
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J M Fine; P Lambin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedicine / [publiée pour l'A.A.I.C.I.G.] Volume: 23 ISSN: 0300-0893 ISO Abbreviation: Biomedicine Publication Date: 1975 Oct |
Date Detail:
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Created Date: 1976-10-20 Completed Date: 1976-10-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361342 Medline TA: Biomedicine Country: FRANCE |
Other Details:
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Languages: eng Pagination: 323-7 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Bence Jones Protein / urine Female Humans Hypergammaglobulinemia / blood*, urine Immunoglobulin A / analysis Immunoglobulin G / analysis Immunoglobulin Heavy Chains / analysis* Immunoglobulin Light Chains / analysis* Immunoglobulin M / analysis Immunoglobulin kappa-Chains / analysis Immunoglobulin lambda-Chains / analysis Leukemia, Lymphoid / blood Liver Cirrhosis / blood Male Middle Aged Multiple Myeloma / blood*, urine Neoplasms / blood Sex Factors Waldenstrom Macroglobulinemia / blood*, urine |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin Heavy Chains; 0/Immunoglobulin Light Chains; 0/Immunoglobulin M; 0/Immunoglobulin kappa-Chains; 0/Immunoglobulin lambda-Chains; 9006-99-9/Bence Jones Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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