Document Detail


Distribution of glycogen and lipids in the ischemic canine left ventricle: biochemical and light and electron microscopic correlates.
MedLine Citation:
PMID:  1208978     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transmural gradients in the contents of glycogen triglycerides, and phospholipids were studied in the dog left ventricle with and without 4 hours of left circumflex artery ligation. In control dogs (patent circumflex), an increasing outer to inner glycogen gradient was observed. After 4 hours of ischemia, subepicardial glycogen content was similar to control values, but midventricular and subendocardial stores were nearly depleted, thus indicating a reversal of the control gradient. These changes were seen biochemically as well as by light and electron microscopic techniques. In the present studies, conclusive evidence for a transmural gradient in tissue triglyceride content was not obtained in either control or ligated dogs. However, an approximate three-fold increase in midventricular and subendocardial triglycerides was observed in ischemic hearts. Regional contents of total tissue phospholipids appeared to be similar across the left ventricular wall in both normal and ischemic left ventricles.
Authors:
M F Crass; P R Sterrett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Recent advances in studies on cardiac structure and metabolism     Volume:  10     ISSN:  0363-5872     ISO Abbreviation:  Recent Adv Stud Cardiac Struct Metab     Publication Date:  1975  
Date Detail:
Created Date:  1976-04-01     Completed Date:  1976-04-01     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0325677     Medline TA:  Recent Adv Stud Cardiac Struct Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  251-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Disease / physiopathology
Dogs
Glycogen / metabolism*
Heart / physiopathology
Heart Ventricles / metabolism*
Lipid Metabolism*
Microscopy, Electron
Myocardium / ultrastructure
Purkinje Cells / metabolism
Triglycerides / metabolism
Chemical
Reg. No./Substance:
0/Triglycerides; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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