Document Detail

Distribution and genotoxic effects after successive exposure to different uranium oxide particles inhaled by rats.
MedLine Citation:
PMID:  16864406     Owner:  NLM     Status:  MEDLINE    
In nuclear fuel cycle facilities, workers may inhale airborne uranium compounds that lead to internal contamination, with various exposure scenarios depending on the workplace. These exposures can be chronic, repeated, or acute, and can involve many different compounds. The effect of uranium after multiple scenarios of exposure is unknown. The aim of this study, therefore, was to investigate the genotoxic and biokinetics consequences of exposure to depleted insoluble uranium dioxide (UO2) by repeated or acute inhalation on subsequent acute inhalation of moderately soluble uranium peroxide (UO4) in rats. The results show that UO2 repeated preexposure by inhalation increases the genotoxic effects of UO4 inhalation, assessed by comet assay, in different cell types, when UO4 exposure alone has no effect. At the same time, the study of UO4 bioaccumulation showed that the UO4 biokinetics in the kidneys, gastrointestinal tract, and excreta, but not in the lungs, were slightly modified by previous UO2 exposures. All these results show that both genotoxic and biokinetics effects of uranium may depend on preexposure and that repeated exposure induces a potentiation effect compared with acute exposure.
Marjorie Monleau; Michel De Méo; Sandrine Frelon; François Paquet; Marie Donnadieu-Claraz; Gérard Duménil; Valérie Chazel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inhalation toxicology     Volume:  18     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-07-25     Completed Date:  2006-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  885-94     Citation Subset:  IM    
IRSN/DRPH/SRBE, Laboratoire de Radiotoxicologie Expérimentale, Pierrelatte Cedex, France.
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MeSH Terms
Air Pollutants, Occupational / classification,  pharmacokinetics,  toxicity*
Body Weight / drug effects
Comet Assay*
Dose-Response Relationship, Drug
Drinking / drug effects
Drug Synergism
Eating / drug effects
Inhalation Exposure
Kidney / drug effects,  pathology
Mutagens / classification,  pharmacokinetics,  toxicity*
Rats, Sprague-Dawley
Specific Pathogen-Free Organisms
Tissue Distribution
Uranium Compounds / classification,  pharmacokinetics,  toxicity*
Reg. No./Substance:
0/Aerosols; 0/Air Pollutants, Occupational; 0/Mutagens; 0/Uranium Compounds; 12036-71-4/uranium peroxide; 1344-57-6/uranium dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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