Document Detail


Distribution and genotoxic effects after successive exposure to different uranium oxide particles inhaled by rats.
MedLine Citation:
PMID:  16864406     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In nuclear fuel cycle facilities, workers may inhale airborne uranium compounds that lead to internal contamination, with various exposure scenarios depending on the workplace. These exposures can be chronic, repeated, or acute, and can involve many different compounds. The effect of uranium after multiple scenarios of exposure is unknown. The aim of this study, therefore, was to investigate the genotoxic and biokinetics consequences of exposure to depleted insoluble uranium dioxide (UO2) by repeated or acute inhalation on subsequent acute inhalation of moderately soluble uranium peroxide (UO4) in rats. The results show that UO2 repeated preexposure by inhalation increases the genotoxic effects of UO4 inhalation, assessed by comet assay, in different cell types, when UO4 exposure alone has no effect. At the same time, the study of UO4 bioaccumulation showed that the UO4 biokinetics in the kidneys, gastrointestinal tract, and excreta, but not in the lungs, were slightly modified by previous UO2 exposures. All these results show that both genotoxic and biokinetics effects of uranium may depend on preexposure and that repeated exposure induces a potentiation effect compared with acute exposure.
Authors:
Marjorie Monleau; Michel De Méo; Sandrine Frelon; François Paquet; Marie Donnadieu-Claraz; Gérard Duménil; Valérie Chazel
Related Documents :
6279116 - Stimulation of the respiratory burst in human neutrophils by crystal phagocytosis.
23703116 - Time course of regional vascular adaptations to low load resistance training with blood...
22513266 - The initial phase for validating the european algorithm for functional assessment prior...
24627716 - Physical activity - an important preanalytical variable.
11690666 - Acute cardiovascular responses to leg-press resistance exercise in heart transplant rec...
16125476 - Measuring end-expiratory lung volume and pulmonary mechanics to detect early lung funct...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inhalation toxicology     Volume:  18     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-07-25     Completed Date:  2006-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  885-94     Citation Subset:  IM    
Affiliation:
IRSN/DRPH/SRBE, Laboratoire de Radiotoxicologie Expérimentale, Pierrelatte Cedex, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aerosols
Air Pollutants, Occupational / classification,  pharmacokinetics,  toxicity*
Animals
Body Weight / drug effects
Comet Assay*
Dose-Response Relationship, Drug
Drinking / drug effects
Drug Synergism
Eating / drug effects
Inhalation Exposure
Kidney / drug effects,  pathology
Male
Mutagens / classification,  pharmacokinetics,  toxicity*
Rats
Rats, Sprague-Dawley
Specific Pathogen-Free Organisms
Tissue Distribution
Uranium Compounds / classification,  pharmacokinetics,  toxicity*
Chemical
Reg. No./Substance:
0/Aerosols; 0/Air Pollutants, Occupational; 0/Mutagens; 0/Uranium Compounds; 12036-71-4/uranium peroxide; 1344-57-6/uranium dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Postnatal lung development: immediate-early gene responses post ozone and LPS exposure.
Next Document:  The effect of nebulized NaHCO3 treatment on "RADS" due to chlorine gas inhalation.