Document Detail

Distribution and functional plasticity of peripheral blood Th(c)17 and Th(c)1 in rheumatoid arthritis.
MedLine Citation:
PMID:  23412693     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to identify and characterize the pro-inflammatory function of IL-17-producing T cell subsets (Th(c)17) in RA. Flow cytometry analysis was performed on peripheral blood from RA patients with inactive or low disease activity (LDA, n = 19) and moderate to high disease activity (HDA, n = 13) to analyze the number and functional activity of Th(c)17 and Th(c)1 cell subsets according to the frequency of IL-2-, TNF-α- and IFN-γ-producers cells, as well as, their cytokine amount. Additionally, 13 age-matched healthy volunteers were added to the study. Our data point to a slight increase in Tc17 frequency in RA patients, more evident in HDA, and a higher ability of Th17 to produce IL-17, whereas a lower production of TNF-α was noted either in Th17 or Tc17 cells, particularly from HDA. A similar decrease was observed in Th(c)1 for almost all studied pro-inflammatory cytokines, with the exception of IL-2, which was increased in Tc1 from LDA patients. Analysing the proportion of pro-inflammatory cytokines-producing cells, a polarization to a Tc1 phenotype seemed to occur in CD8 T cells, while CD4 T cells appear to be decreased in their frequency of IFN-γ-producing cells. Taken together, the functional plasticity features of Th17 and Tc17 cells suggest a particular contribution to the local cytokine production, pointing an underestimated role, namely of Tc1 and Tc17 cells, in the RA pathophysiology.
Ana Henriques; Vera Gomes; Cátia Duarte; Susana Pedreiro; Tiago Carvalheiro; Marlene Areias; Armando Caseiro; António José Gabriel; Paula Laranjeira; Maria Luísa Pais; José António Pereira da Silva; Artur Paiva
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Publication Detail:
Type:  Journal Article     Date:  2013-02-15
Journal Detail:
Title:  Rheumatology international     Volume:  33     ISSN:  1437-160X     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-23     Completed Date:  2014-03-06     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2093-9     Citation Subset:  IM    
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MeSH Terms
Arthritis, Rheumatoid / blood*,  pathology
Cell Count
Flow Cytometry
Middle Aged
T-Lymphocyte Subsets / pathology*
Th1 Cells / pathology*
Th17 Cells / pathology*

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