Document Detail


Distribution of ethambutol in primate tissues and cells.
MedLine Citation:
PMID:  6786149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ethambutol (EMB) concentrations that kill Mycobacterium tuberculosis in vitro accumulated in squirrel monkey tissues and cells known to be sites of tubercular infections. After oral administration of a clinically relevant 25 mg/kg dose, the whole-body distribution and intracellular localization of EMB were studied by radioautography. Tissue concentrations of drug were assayed by radiochemical and microbiological methods. The EMB was distributed rapidly and widely to most body tissues including lung and localized within pulmonary alveolar and axillary lymph node macrophages. The EMB in lung at 2 and 5 h after drug administration was markedly higher than the corresponding plasma concentrations and exceeded concentrations that are bactericidal in vitro for tubercle bacilli. These observations may help explain the early bactericidal activity of EMB in humans. Similarities in plasma and tissue concentrations of the drug in both species suggest the usefulness of the squirrel monkey as a model for the use of EMB in humans.
Authors:
R H Liss; R J Letourneau; J P Schepis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  123     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  529-32     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Autoradiography
Ethambutol / blood,  metabolism*
Humans
Lung / cytology
Macrophages / physiology
Microscopy, Electron
Models, Biological
Mycobacterium tuberculosis / pathogenicity
Pulmonary Alveoli / cytology,  ultrastructure
Saimiri
Tissue Distribution
Chemical
Reg. No./Substance:
74-55-5/Ethambutol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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