Document Detail


Distribution of epithelial membrane antigen in eccrine poroma.
MedLine Citation:
PMID:  1720746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using immunohistochemical methods, we investigated the distribution of epithelial membrane antigen (EMA) on the normal eccrine gland, eccrine poroma and hidroacanthoma simplex. Granular membrane-associated reaction of EMA was detected on the outer cells of both the intraepidermal and the upper portion of intradermal eccrine ducts, as well as on the luminal surfaces and intercellular canaliculi of eccrine glands. Clear immunolabeling was also present in the tumor cells of eccrine poroma and hidroacanthoma simplex. Thus, it is suggested that the constituent cells of these tumors originate from the outer cells of the intraepidermal and/or the upper portion of the intradermal eccrine ducts. There was no immunolabeling for EMA on the tumor cells of seborrheic keratosis and basal cell carcinoma. Immunohistochemical staining for EMA is a useful tool for the diagnosis of skin appendage tumors.
Authors:
M Takanashi; A Urabe; J Nakayama; Y Hori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Dermatologica     Volume:  183     ISSN:  0011-9075     ISO Abbreviation:  Dermatologica     Publication Date:  1991  
Date Detail:
Created Date:  1992-01-10     Completed Date:  1992-01-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0211607     Medline TA:  Dermatologica     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  187-90     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenoma, Sweat Gland / immunology*,  pathology
Antigens, Neoplasm / analysis*
Carcinoembryonic Antigen / analysis
Carcinoma, Basal Cell / immunology
Cell Membrane / immunology
Cytoplasm / immunology
Dermatitis, Seborrheic / immunology
Eccrine Glands / immunology,  pathology
Epithelium / immunology
Humans
Immunohistochemistry
Keratins / analysis
Membrane Glycoproteins / analysis*
Mucin-1
Reproducibility of Results
Skin Neoplasms / immunology*,  pathology
Tumor Markers, Biological / analysis*
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Carcinoembryonic Antigen; 0/Membrane Glycoproteins; 0/Mucin-1; 0/Tumor Markers, Biological; 68238-35-7/Keratins

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