Document Detail


Distribution of eosinophils along and across successive segments of the rat digestive tract: a quantitative study.
MedLine Citation:
PMID:  9276344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Density of eosinophils stained by substrateless DAB reaction was measured in the successive segments and the successive layers of rat digestive tract using a semiautomatic computerized image analysis system. The results were calculated in a dual way: per area of the entire layer and per area of its connective tissue compartment, in which the eosinophils were located (extremely small number of intraepithelial and intramuscular eosinophils was not included in the analysis). The density of eosinophils in the successive segments of the digestive tract seemed to depend primarily on the time of contact between the contents and the wall of the segment, being the highest in regions of food/content retention (fundus of the stomach, cecum) and the lowest in regions of rapid passage (esophagus, pylorus, duodenum). When eosinophil density in the successive layers was compared, its gradual decrease in the successive layers (villi>lamina propria>submucosa>muscularis) was observed in almost the entire small intestine and lower values in submucosa compared to mucosa were also evident in the stomach, duodenum and small intestine. It seems that there is a decreasing gradient of chemoattractants for eosinophils dependent of the distance from the lumen and the contents of the digestive tract. However, this decreasing pattern appeared only when the density was calculated for the area of the connective tissue compartment suggesting that this method of calculation more reliably reflects the distribution of eosinophils and should be used in future quantitative studies on tissue eosinophils.
Authors:
A Furgał; J A Litwin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society     Volume:  35     ISSN:  0239-8508     ISO Abbreviation:  Folia Histochem. Cytobiol.     Publication Date:  1997  
Date Detail:
Created Date:  1997-10-08     Completed Date:  1997-10-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8502651     Medline TA:  Folia Histochem Cytobiol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  155-63     Citation Subset:  IM    
Affiliation:
Department of Histology, Jagiellonian University School of Medicine, Kraków, Poland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cecum / cytology
Digestive System / anatomy & histology,  cytology*
Duodenum / cytology
Eosinophils / cytology*
Esophagus / cytology
Ileum / cytology
Image Cytometry
Jejunum / cytology
Leukocyte Count
Pylorus / cytology
Rats
Rats, Wistar
Rectum / cytology
Stomach / cytology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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