Document Detail

Distribution and dynamics of transcription-associated proteins during parvovirus infection.
MedLine Citation:
PMID:  23035221     Owner:  NLM     Status:  MEDLINE    
Canine parvovirus (CPV) infection leads to reorganization of nuclear proteinaceous subcompartments. Our studies showed that virus infection causes a time-dependent increase in the amount of viral nonstructural protein NS1 mRNA. Fluorescence recovery after photobleaching showed that the recovery kinetics of nuclear transcription-associated proteins, TATA binding protein (TBP), transcription factor IIB (TFIIB), and poly(A) binding protein nuclear 1 (PABPN1) were different in infected and noninfected cells, pointing to virus-induced alterations in binding dynamics of these proteins.
Teemu O Ihalainen; Sami F Willman; Einari A Niskanen; Outi Paloheimo; Hanna Smolander; Juha P Laurila; Minna U Kaikkonen; Maija Vihinen-Ranta
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-03
Journal Detail:
Title:  Journal of virology     Volume:  86     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-01-28     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13779-84     Citation Subset:  IM    
Nanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä, Finland.
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MeSH Terms
Cell Compartmentation
Parvoviridae Infections / metabolism*
Parvovirus, Canine / isolation & purification
Subcellular Fractions / metabolism*
Transcription Factors / metabolism*
Reg. No./Substance:
0/Transcription Factors

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