Document Detail


Distribution and development of short-wavelength cones differ between Macaca monkey and human fovea.
MedLine Citation:
PMID:  9888315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Macaca monkey and humans have three cone types containing either long-wavelength (L), medium-wavelength (M), or short-wavelength (S)-specific opsin. The highest cone density is found in the fovea, which mediates high visual acuity. Most studies agree that the adult human fovea has a small S cone-free area, but data are conflicting concerning S-cone numbers in the adult Macaca monkey fovea, and little evidence exists for how either primate fovea develops its characteristic cone pattern. Single- and double-label in situ hybridization and immunocytochemistry have been used to determine the pattern of foveal S cones in both the fetal and adult Macaca and human. Both labels find a clear difference at all ages between monkey and human. Adult humans have a distinct but variable central zone about 100 microm wide that lacks S cones and is surrounded by a ring in which the S-cone density is 8%. This S cone-free zone is detectable at fetal week 15.5 (Fwk15.5), shortly after S opsin is expressed, and is similar to the adult by Fwk20.5. Adult monkey foveas have an overall S-cone foveal density of 10%, with several areas lacking a few S cones that are not coincident with the area of highest cone density. A surrounding zone at 200-microm eccentricity has an S-cone density averaging 25%, but, by 800 microm, this has decreased to 11%. Fetal day 77-135 monkeys all have a distribution and density of foveal S cones similar to adults, although the high-density ring is not obvious in fetal retinas. Estimates of the numbers of S cones missing in the fetal human fovea range from 234 to 328, whereas no more than 40 are missing in the fetal monkey. These results show that, in these two trichromatic primates, S-cone distribution and the developmental mechanisms determining S-cone topography are markedly different from the time that S cones are first detected.
Authors:
K Bumsted; A Hendrickson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  403     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  502-16     Citation Subset:  IM    
Affiliation:
Department of Biological Structure, University of Washington, Seattle 98195, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aging / physiology*
Animals
Fetus
Fovea Centralis / anatomy & histology*,  cytology,  growth & development
Humans
In Situ Hybridization
Macaca fascicularis / growth & development*
Macaca nemestrina / growth & development*
Middle Aged
RNA, Messenger / genetics
Retinal Cone Photoreceptor Cells / cytology*
Rod Opsins / genetics
Species Specificity
Transcription, Genetic
Grant Support
ID/Acronym/Agency:
EY04536/EY/NEI NIH HHS; T32-EY07031/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/Rod Opsins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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