Document Detail


Distribution and correlates of lipoproteins and their subclasses in black and white young adults. The Bogalusa Heart Study.
MedLine Citation:
PMID:  11730819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoprotein subclasses vary in CAD risk potential, but their distribution and correlates are not well documented in black and white young adults. A subsample of 449 (32%) young adults (67% white, 58% female) aged 20-37 years examined in the Bogalusa Heart Study had lipoprotein subclasses measured in terms of cholesterol by vertical spin density-gradient ultracentrifugation. LDL subclass pattern was characterized as either predominantly LDL(1) (large, buoyant), LDL(2) (intermediate) or LDL(3) (small, dense). Whites had significantly higher levels of VLDL, VLDL(3), and LDL and lower levels of HDL(2) and HDL(3) than blacks. White females had significantly higher levels of HDL(2) than white males. Visceral fatness, measured as waist circumference, and race were the major contributors to the explained variance (6-22%) of these lipoproteins, with adverse trends seen among whites and persons with large waist circumferences. Sex (males>females), waist circumference (positive), HDL(2) (negative), and HDL(3) (positive) were the predictor variables for the likelihood of having the LDL(3) pattern. When glucose and insulin were included in the multivariate analysis, insulin (positive), sex (males>females), HDL(2) (negative) and HDL(3) (positive) became significant predictors of LDL(3) pattern. Positive parental history of CAD was associated with LDL (P=0.009) in white males, and HDL(2) (P=0.008) and LDL(3) subclass pattern (P=0.038) in white females; whereas none in blacks. The observed correlates of lipoprotein subclasses and patterns need to be considered in estimating CAD risk in young adults.
Authors:
S R Srinivasan; J P Segrest; A M Elkasabany; G S Berenson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Atherosclerosis     Volume:  159     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-03     Completed Date:  2002-02-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  391-7     Citation Subset:  IM    
Affiliation:
Tulane Center for Cardiovascular Health, Tulane University School of Tropical Hygiene and Public Health, Suite 2140, 1440 Canal Street, New Orleans, LA 70112, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group / genetics*
Age Distribution
Coronary Artery Disease / diagnosis*,  ethnology*
Cross-Sectional Studies
European Continental Ancestry Group / genetics*
Female
Health Surveys
Humans
Incidence
Lipoproteins / blood*,  classification*
Lipoproteins, HDL / blood
Lipoproteins, LDL / blood
Lipoproteins, VLDL / blood
Male
Probability
Risk Assessment
Risk Factors
Sampling Studies
Sex Distribution
Sex Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
HL38844/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL

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