Document Detail


Distribution of coronary artery flow to the canine right atrium and sinoatrial node.
MedLine Citation:
PMID:  844147     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed segmental distribution of blood flow to the right atrium and the region of the sinoatrial node using micropheres (7-10 mum) in 20 anesthetized dogs. Mean right atrial flow averaged 83+/-7 (SE) ml/min X 100 g, which was 56% of the left ventricular blood flow. The distribution of right atrial flow was not homogeneous. For example, flow to anterior right atriaater (105+/-8 ml/min X 100 g) than mean right atrial flow. Following ligation of the sinus node artery, perfusion of the segment containing the sinus node decreased by only 36%. Relative preservation of perfusion to the sinus node following sinus node artery ligation may explain why ligation of the sinus node artery does not alter heart rate. Furthermore, we also found that cannulation and pump perfusion of the sinus node artery at pressures 10 and 50 mm Hg greater than systolic pressure did not alter the distribution of right atrial flow. Thus, because cannulation and perfusion of the sinus node artery do not artifactually distort regional right atrial blood flow, we conclude that this should be a useful method for evaluating responsiveness of the sinus node to various interventions.
Authors:
C W White; M L Marcus; F M Abboud
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  40     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-05-20     Completed Date:  1977-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  342-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Animals
Blood Flow Velocity
Blood Pressure / drug effects
Coronary Circulation* / drug effects
Coronary Disease / physiopathology
Dogs
Female
Heart Atria*
Heart Rate / drug effects
Male
Norepinephrine / pharmacology
Sinoatrial Node*
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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