| Distribution of coronary arterial capacitance in a canine model. | |
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MedLine Citation:
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PMID: 9480957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The capacitative properties of the major left coronary arteries, left main (LM), left anterior descending (LAD), and left circumflex (LCX), were studied in 19 open-chest isolated dog hearts. Capacitance was determined by using ramp perfusion and a left ventricular-to-coronary shunt diastolic decay method; both methods gave similar results, indicating a minimal systolic capacitative component. Increased pericardial pressure (PCP), 25 mmHg, was used to experimentally alter transmural wall pressure. The response to increased PCP was different in the LAD vs. LCX; increasing PCP decreased capacitance in the LCX but increased capacitance in the LAD. This may have been due to the different intramural vs. epicardial volume distribution of these vessels and a decrease in intramural tension during increased PCP. Increased PCP decreased LCX capacitance by approximately 13%, but no changes in conductance or zero flow pressure intercept occurred in any of the three vessels, i. e., evidence against the waterfall theory of vascular collapse at these levels of PCP. Coronary arterial capacitance was also linearly related to perfusion pressure. |
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Authors:
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A S Lader; R S Smith; G C Phillips; J E McNamee; F L Abel |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 84 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-04-09 Completed Date: 1998-04-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 954-62 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Coronary Circulation / physiology* Coronary Vessels / physiology* Diastole / physiology Dogs Female Heart Function Tests Male Pericardium / physiology Vascular Capacitance / physiology* Vascular Resistance / physiology Ventricular Function |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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