Document Detail


Distribution of collagen types I, III, and V in pregnant mouse endometrium.
MedLine Citation:
PMID:  17453912     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Decidualization in mice comprises a deep remodeling of extracellular matrix (ECM) components of the endometrium. In a previous biochemical study we showed that collagen types I and III are present in both pregnant and nonpregnant mouse endometrium, whereas collagen type V is expressed exclusively after the onset of decidualization. The distribution of collagen types in the pregnant mouse endometrium and possible changes of these molecular types in the different regions of the decidua is, however, not known. Using immunofluorescence and confocal microscopy we showed the presence of collagen types I, III, and V in the endometrial stroma of implantation and interimplantation sites from days 5 to 8 of pregnancy in the mouse. Collagen type III was chiefly expressed in the implantation sites and was the only collagen type to be present in the materno-fetal interface on the day of the embryo implantation. However, collagen type I was the predominant collagen in the interimplantation sites. Collagen type V was weakly expressed in the nondecidualized stroma during all periods but was expressed in larger amounts in the decidualized areas on day 7 of pregnancy, simultaneously with the accumulation of thick collagen fibrils in the same region. The highest immunofluorescence labeling for the three types of collagen was observed on day 7 when the antimesometrial decidual tissue achieved its greatest development. These data support previous studies that showed an intense ECM remodeling of the mouse endometrial stroma during the beginning of pregnancy. This outstanding remodeling may be important to stabilize placental anchorage.
Authors:
Karin Spiess; Walcy R Teodoro; Telma M T Zorn
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Connective tissue research     Volume:  48     ISSN:  0300-8207     ISO Abbreviation:  Connect. Tissue Res.     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-06-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0365263     Medline TA:  Connect Tissue Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-108     Citation Subset:  IM    
Affiliation:
Laboratory of Biology of Reproduction and Extracellular Matrix, Department of Cell and Development Biology, Institute of Biomedical Sciences, University of São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Collagen Type I / metabolism*
Collagen Type III / metabolism*
Collagen Type V / metabolism*
Embryo Implantation
Endometrium / cytology,  metabolism*
Female
Humans
Mice
Pregnancy / metabolism*
Chemical
Reg. No./Substance:
0/Collagen Type I; 0/Collagen Type III; 0/Collagen Type V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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