Document Detail


Distribution of catecholamines, serotonin, and their major metabolites in the rat cingulate, piriform-entorhinal, somatosensory, and visual cortex: a biochemical survey using high-performance liquid chromatography.
MedLine Citation:
PMID:  2450286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The catecholamines noradrenaline (NA), dopamine (DA), adrenaline (AD), the indoleamine 5-hydroxytryptamine (5-HT; serotonin), as well as some of their major metabolites were assayed by high-performance liquid chromatography (HPLC) with electrochemical detection, in four well-defined areas of the rat cerebral cortex: anterior cingulate (CIN;Cg1 and Cg3), piriform and entorhinal (PiEn), hind-limb primary somatosensory (SSC;HL) and primary visual (VIS; Oc1M and Oc1B). The concentrations of NA and that of its main metabolite 3-methoxy-4-hydroxyphenylglycol were highest in PiEn, had intermediate values in CIN and were lowest for SSC and VIS cortices. The DA levels were also highest in PiEn, intermediate in CIN, while the lowest values were in SSC and VIS cortices. The different DA/NA ratios support the hypothesis that they are indeed independent neurotransmitters. In addition, the levels of 3,4-dihydroxyphenylacetic acid, homovanillic acid and 3-methoxytyramine paralleled the distribution of DA, thus confirming the presence of release sites, even in regions in which the low levels of this catecholamine could be interpreted simply as the precursor of NA. Traces of AD were detected in all the regions examined. The 5-HT contents, as well as that of its precursor 5-hydroxy-1-tryptophan and that of its metabolite 5-hydroxyindole-3-acetic acid were also found to be non-homogenous, with the highest levels measured in the PiEn and CIN regions.
Authors:
T A Reader; L Grondin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurochemical research     Volume:  12     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-04-13     Completed Date:  1988-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1087-97     Citation Subset:  IM    
Affiliation:
Département de physiologie, Faculté de Médecine, Université de Montréal, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / analysis
Animals
Catecholamines / metabolism*
Cerebral Cortex / analysis*
Chromatography, High Pressure Liquid
Gyrus Cinguli / analysis
Homovanillic Acid / analysis
Hydroxyindoleacetic Acid / analysis
Male
Rats
Rats, Inbred Strains
Serotonin / metabolism*
Somatosensory Cortex / analysis
Visual Cortex / analysis
Chemical
Reg. No./Substance:
0/Catecholamines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid

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