Document Detail


Distribution of catecholaminergic and peptidergic cells in the gerbil medial amygdala, caudal preoptic area and caudal bed nuclei of the stria terminalis with a focus on areas activated at ejaculation.
MedLine Citation:
PMID:  21087661     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The posterodorsal preoptic nucleus (PdPN), lateral part of the posterodorsal medial amygdala (MeApd) and medial part of the medial preoptic nucleus (MPNm) are activated at ejaculation in male gerbils as assessed by Fos expression. We sought to immunocytochemically visualize substance P (SP), cholecystokinin (CCK), oxytocin, vasopressin and tyrosine hydroxylase (TH), a catecholaminergic marker, in the mating-activated cells, but the need for colchicine precluded behavioral testing. Instead, we detailed distributions of cells containing these molecules in the medial amygdala, caudal preoptic area and caudal bed nuclei of the stria terminalis (BST) and quantified their densities in the PdPN, MPNm and lateral MeApd for comparison to densities previously assessed for mating-activated efferents from these sites. TH cells were as dense in the PdPN and lateral MeApd as activated efferents to the anteroventral periventricular nucleus. In the lateral MeApd, TH cells were grouped where cells activated at ejaculation are clustered and where CCK cells form a ball. Lateral MeApd CCK cells and PdPN SP cells were as dense as activated efferents to the principal BST. Oxytocinergic PdPN cells and SP cells in the MPNm were as dense as mating-activated efferents to the lateral MeApd. If some oxytocin cells in the PdPN project to the neurohypophysis, as in rats, they could be a source of the oxytocin secreted at ejaculation. Since gerbils are monogamous and biparental, it was also interesting that, unlike monogamous prairie voles, they had few TH cells in the MeApd or dorsal BST, resembling promiscuous rats, hamsters and meadow voles.
Authors:
Danielle A Simmons; Pauline Yahr
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-11-16
Journal Detail:
Title:  Journal of chemical neuroanatomy     Volume:  41     ISSN:  1873-6300     ISO Abbreviation:  J. Chem. Neuroanat.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-04-07     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8902615     Medline TA:  J Chem Neuroanat     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  13-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Neurobiology and Behavior, University of California, 2205 McGaugh Hall, Irvine, CA 92697-4550, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amygdala / chemistry,  cytology*,  metabolism
Animals
Arvicolinae
Cell Nucleus / metabolism
Cholecystokinin / analysis,  metabolism
Ejaculation / physiology*
Female
Gerbillinae
Hypothalamus / chemistry,  cytology*,  metabolism
Immunohistochemistry
Male
Oxytocin / analysis,  metabolism
Preoptic Area / chemistry,  cytology*,  metabolism
Septal Nuclei / chemistry,  cytology*,  metabolism
Substance P / analysis,  metabolism
Tyrosine 3-Monooxygenase / analysis,  metabolism
Vasopressins / analysis,  metabolism
Grant Support
ID/Acronym/Agency:
MH14599/MH/NIMH NIH HHS; MH26481/MH/NIMH NIH HHS; R01 MH026481-24/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
11000-17-2/Vasopressins; 33507-63-0/Substance P; 50-56-6/Oxytocin; 9011-97-6/Cholecystokinin; EC 1.14.16.2/Tyrosine 3-Monooxygenase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Tumor selectivity of stealth multi-functionalized superparamagnetic iron oxide nanoparticles.
Next Document:  The "thrifty" gene encoding Ahsg/Fetuin-A meets the insulin receptor: Insights into the mechanism of...