| Distribution of cardiac iron measured by magnetic resonance imaging (MRI)-R*2. | |
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MedLine Citation:
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PMID: 21031515 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: To assess regional iron distribution by magnetic resonance imaging (MRI)-R(2)* within the heart of patients with β-thalassemia major (TM) and other iron overload diseases. MATERIALS AND METHODS: Breathhold electrocardiogram (ECG)-gated MRI (1.5 T) of the heart was used for the measurement of transverse relaxation rates R(2)* in 32 patients (11-79 years). In a mid-papillary short-axis slice divided into septal, anterior, lateral, and posterior quadrants, R(2)* was analyzed from region of interest (ROI)-based signal intensities from 12 echo times (TE = 1.3-26 msec). Typical boundary effects were evaluated in detail. RESULTS: The segmentation of the cardiac wall resulted in highly significant correlations of R(2)* between septal and all other quadrants. In the patient group with R(2)* < 50 s(-1) (normal), all quadrants show higher normalized median rates (126%-174%) than the septum (P < 10(-4)), while this was relatively smaller in the group with septal R(2)* > 50 s(-1). Typical boundary effects on segmental R(2)* from blood, lung tissue, epicardial fat, and hepatic iron could not be easily separated from segmental iron distribution. CONCLUSION: The measurement of MRI-R2* in the interventricular septum is the least affected method by boundary effects to detect patients with iron overload at risk of developing heart failure. |
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Authors:
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Jin Yamamura; Regine Grosse; Joachim Graessner; Gritta E Janka; Gerhard Adam; Roland Fischer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1104-9 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley-Liss, Inc. |
Affiliation:
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University Medical Center Hamburg-Eppendorf, Hamburg, Germany. j.yamamura@uke.uni-hamburg.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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