Document Detail


Distribution of calpains and calpastatin in human blood cells.
MedLine Citation:
PMID:  2838026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The occurrence and molecular sizes of calpains and calpastatin in the lysates of human erythrocytes, platelets, lymphocytes/monocytes, and polymorphonuclear cells were studied by immunoelectrophoretic blot analysis. The basic uniformity among these cells of the 85-kDa and 83-kDa heavy subunits of low- and high-Ca2+-requiring calpains I and II, respectively, and of the 29-kDa light subunit was confirmed. Molecular diversity of calpastatin species, ranging from 70 kDa to 107 kDa, among different blood cells was also shown. The obtained data are consistent with those known for other animal tissues, thus settling hitherto uncertain or rather controversial issues on the distribution of calpains and calpastatin in human blood cells.
Authors:
E Takano; Y H Park; A Kitahara; Y Yamagata; R Kannagi; T Murachi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemistry international     Volume:  16     ISSN:  0158-5231     ISO Abbreviation:  Biochem. Int.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-07-15     Completed Date:  1988-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100311     Medline TA:  Biochem Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  391-5     Citation Subset:  IM    
Affiliation:
Department of Clinical Science and Laboratory Medicine, Kyoto University Faculty of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Blood Platelets / metabolism*
Calcium-Binding Proteins / blood*
Calpain / blood*
Erythrocytes / metabolism*
Humans
Leukocytes / metabolism*
Lymphocytes / metabolism
Molecular Weight
Monocytes / metabolism
Neutrophils / metabolism
Protease Inhibitors / blood*
Chemical
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/Protease Inhibitors; 79079-11-1/calpastatin; EC 3.4.22.-/Calpain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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