| Distribution of break points in human structural rearrangements. | |
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MedLine Citation:
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PMID: 6340471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We attempted to resolve the issue on the location of breakages in patients with structural rearrangements, that is, whether they are located within the light band or are at the interface between a G-dark and a G-light band. Three types of structural rearrangements (inverted duplications, isodicentrics, and rings) were studied as they are capable of providing information not obtainable from other rearrangements because of reasons given in the RATIONALE. We found that break points are primarily located within the G-light bands; a small number of breaks are located in G-dark bands. Breakages at the interface were exceedingly rare. The possibility that they are, in fact, located at the interface of subbands within either light or dark bands appears tenuous. Contrary to what is described in the literature, terminal deletions are not useful in the determining of break points. |
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Authors:
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Y Nakagome; T Matsubara; H Fujita |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: American journal of human genetics Volume: 35 ISSN: 0002-9297 ISO Abbreviation: Am. J. Hum. Genet. Publication Date: 1983 Mar |
Date Detail:
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Created Date: 1983-05-05 Completed Date: 1983-05-05 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0370475 Medline TA: Am J Hum Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 288-300 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Aberrations* Chromosome Banding Chromosome Inversion Humans Karyotyping Translocation, Genetic |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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