| Distribution of apoptosis-related proteins in sporadic Creutzfeldt-Jakob disease. | |
| | |
MedLine Citation:
|
PMID: 20138848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Apoptosis is one mode of programmed cell death in sporadic Creutzfeldt-Jakob disease (sCJD). Distribution of affected brain regions varies between subtypes of sCJD. To compare apoptosis-related proteins representing different stages of cell death, we evaluated 30 anatomical regions for PARP, NF-kappaB, C-Jun, caspase 3 and 9, and BAX immunoreactivity in 12 sCJD cases of MM-1, MV-1, VV-2, and MV-2 subtypes, and 4 control brains. Chi-square test was used to compare the regional presence of immunoreactivities in sCJD cases and controls. The total number of subregions showing neuronal immunoreactivity for any apoptosis-related protein, in particular caspase-3, BAX, and PARP, was significantly higher in sCJD than controls, differed between subtypes of sCJD, and inversely correlated with duration of illness. Thus, sCJD subtypes are both qualitatively and regionally distinct in the predominance of apoptosis-related proteins, confirming regional vulnerabilities of sCJD subtypes that potentially reflect distinct responses to pathogenetic events. |
| | |
Authors:
|
Gabor G Kovacs; Herbert Budka |
Related Documents
:
|
20979698 - Anti-cancer effects of phyllanthus urinaria and relevant mechanisms. 17380098 - Activation of intrinsic apoptotic pathway by re-188 irradiation and paclitaxel in coron... 16458118 - Petrotetrayndiol a induces cell cycle arrest and apoptosis in sk-mel-2 human melanoma c... 10438458 - Role of poly(adp-ribose) polymerase (parp) cleavage in apoptosis. caspase 3-resistant p... 22280068 - The role of signal transducer and activator of transcription-2 in the interferon response. 6745528 - Chemical interactions and compromised immune system. |
Publication Detail:
|
Type: Journal Article Date: 2010-02-06 |
Journal Detail:
|
Title: Brain research Volume: 1323 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-08-13 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 192-9 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Institute of Neurology, Medical University of Vienna, and Austrian Reference Centre for Human Prion Diseases, Vienna, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Apoptosis* Brain / metabolism*, pathology Caspase 3 / metabolism Caspase 9 / metabolism Cell Count Chi-Square Distribution Creutzfeldt-Jakob Syndrome / metabolism*, pathology Female Humans Immunohistochemistry Male Middle Aged NF-kappa B / metabolism Neurons / metabolism*, pathology Proto-Oncogene Proteins c-jun / metabolism bcl-2-Associated X Protein / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/NF-kappa B; 0/Proto-Oncogene Proteins c-jun; 0/bcl-2-Associated X Protein; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Properties of gamma frequency oscillatory activity induced in hippocampal slices from the adult GAD6...
Next Document: Developmental appearance and disappearance of cortical events and oscillations in infant rats.