Document Detail


Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies.
MedLine Citation:
PMID:  16338465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This work was designed to study the expression of the vasodilator peptide angiotensin-(1-7) [Ang-(1-7)] and its generating enzyme (ACE2) in the uteroplacental interface. Placentas were obtained from 11 early pregnancy failures (5 miscarriages and 6 ectopic pregnancies), 15 normotensive, and 10 preeclamptic gestations. In placental villi, the main sites of immunocytochemical expression of Ang-(1-7) and ACE2 were the syncytiotrophoblast, cytotrophoblast, endothelium and vascular smooth muscle of primary and secondary villi. Syncitial Ang-(1-7) expression in samples obtained from miscarriages and ectopic pregnancies was increased compared to normal term pregnancy [2.0 (2.0-2.25 for the 25 and 75% interquartile range) vs 1.3 (1.0-1.9), p<0.01]. In the maternal stroma, Ang-(1-7) and ACE2 were expressed in the invading and intravascular trophoblast and in decidual cells in all 3 groups. Ang-(1-7) and ACE2 staining was also found in arterial and venous endothelium and smooth muscle of the umbilical cord. The expression of Ang-(1-7) and ACE2 was similar in samples obtained from normal term or preeclamptic pregnancies, except for increased expression of ACE2 in umbilical arterial endothelium in preeclampsia [0.5 (0.5-0.8) vs 0.0 (0.0-0.0), p<0.01]. The uteroplacental location of Ang-(1-7) and ACE2 in pregnancy suggests an autocrine function of Ang-(1-7) in the vasoactive regulation that characterizes placentation and established pregnancy.
Authors:
G Valdés; L A A Neves; L Anton; J Corthorn; C Chacón; A M Germain; D C Merrill; C M Ferrario; R Sarao; J Penninger; K B Brosnihan
Related Documents :
2669495 - Ca 125 in the epithelium closely related to the embryonic ectoderm: the periderm and th...
12107445 - Presence of fetal dna in maternal plasma decades after pregnancy.
14580375 - Apoptosis of extravillous trophoblast cells limits the trophoblast invasion in uterine ...
10097785 - Decidual mast cells might be involved in the onset of human first-trimester abortion.
3238175 - Effects of intralipid and hydrocortisone upon human fetal lung cell cultures.
23231845 - Long qt syndrome in pregnancy: are vaginal delivery and use of oxytocin permitted? a ca...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2005-04-25
Journal Detail:
Title:  Placenta     Volume:  27     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    2006 Feb-Mar
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-03-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  200-7     Citation Subset:  IM    
Affiliation:
Departamento Nefrología, Facultad Medicina Universidad Católica Santiago, Chile.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angiotensin I / analysis*,  metabolism
Carboxypeptidases / analysis*,  metabolism
Female
Humans
Immunohistochemistry
Peptide Fragments / analysis*,  metabolism
Peptidyl-Dipeptidase A
Placenta / chemistry*,  enzymology,  metabolism
Pre-Eclampsia / metabolism
Pregnancy / metabolism*
Pregnancy Complications / enzymology,  metabolism*
Grant Support
ID/Acronym/Agency:
HD42631/HD/NICHD NIH HHS; HL51952/HL/NHLBI NIH HHS; HL67363/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/angiotensin I (1-7); 9041-90-1/Angiotensin I; EC 3.4.-/Carboxypeptidases; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.17.-/angiotensin converting enzyme 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The kinase p38 regulates peroxisome proliferator activated receptor-gamma in human trophoblasts.
Next Document:  Placental and fetal growth retardation following partial progesterone withdrawal in rat pregnancy.