| Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies. | |
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MedLine Citation:
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PMID: 16338465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This work was designed to study the expression of the vasodilator peptide angiotensin-(1-7) [Ang-(1-7)] and its generating enzyme (ACE2) in the uteroplacental interface. Placentas were obtained from 11 early pregnancy failures (5 miscarriages and 6 ectopic pregnancies), 15 normotensive, and 10 preeclamptic gestations. In placental villi, the main sites of immunocytochemical expression of Ang-(1-7) and ACE2 were the syncytiotrophoblast, cytotrophoblast, endothelium and vascular smooth muscle of primary and secondary villi. Syncitial Ang-(1-7) expression in samples obtained from miscarriages and ectopic pregnancies was increased compared to normal term pregnancy [2.0 (2.0-2.25 for the 25 and 75% interquartile range) vs 1.3 (1.0-1.9), p<0.01]. In the maternal stroma, Ang-(1-7) and ACE2 were expressed in the invading and intravascular trophoblast and in decidual cells in all 3 groups. Ang-(1-7) and ACE2 staining was also found in arterial and venous endothelium and smooth muscle of the umbilical cord. The expression of Ang-(1-7) and ACE2 was similar in samples obtained from normal term or preeclamptic pregnancies, except for increased expression of ACE2 in umbilical arterial endothelium in preeclampsia [0.5 (0.5-0.8) vs 0.0 (0.0-0.0), p<0.01]. The uteroplacental location of Ang-(1-7) and ACE2 in pregnancy suggests an autocrine function of Ang-(1-7) in the vasoactive regulation that characterizes placentation and established pregnancy. |
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Authors:
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G Valdés; L A A Neves; L Anton; J Corthorn; C Chacón; A M Germain; D C Merrill; C M Ferrario; R Sarao; J Penninger; K B Brosnihan |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2005-04-25 |
Journal Detail:
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Title: Placenta Volume: 27 ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 2006 Feb-Mar |
Date Detail:
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Created Date: 2005-12-12 Completed Date: 2006-03-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
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Languages: eng Pagination: 200-7 Citation Subset: IM |
Affiliation:
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Departamento Nefrología, Facultad Medicina Universidad Católica Santiago, Chile. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin I
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analysis*,
metabolism Carboxypeptidases / analysis*, metabolism Female Humans Immunohistochemistry Peptide Fragments / analysis*, metabolism Peptidyl-Dipeptidase A Placenta / chemistry*, enzymology, metabolism Pre-Eclampsia / metabolism Pregnancy / metabolism* Pregnancy Complications / enzymology, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HD42631/HD/NICHD NIH HHS; HL51952/HL/NHLBI NIH HHS; HL67363/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/angiotensin I (1-7); 9041-90-1/Angiotensin I; EC 3.4.-/Carboxypeptidases; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.17.-/angiotensin converting enzyme 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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