Document Detail

Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies.
MedLine Citation:
PMID:  16338465     Owner:  NLM     Status:  MEDLINE    
This work was designed to study the expression of the vasodilator peptide angiotensin-(1-7) [Ang-(1-7)] and its generating enzyme (ACE2) in the uteroplacental interface. Placentas were obtained from 11 early pregnancy failures (5 miscarriages and 6 ectopic pregnancies), 15 normotensive, and 10 preeclamptic gestations. In placental villi, the main sites of immunocytochemical expression of Ang-(1-7) and ACE2 were the syncytiotrophoblast, cytotrophoblast, endothelium and vascular smooth muscle of primary and secondary villi. Syncitial Ang-(1-7) expression in samples obtained from miscarriages and ectopic pregnancies was increased compared to normal term pregnancy [2.0 (2.0-2.25 for the 25 and 75% interquartile range) vs 1.3 (1.0-1.9), p<0.01]. In the maternal stroma, Ang-(1-7) and ACE2 were expressed in the invading and intravascular trophoblast and in decidual cells in all 3 groups. Ang-(1-7) and ACE2 staining was also found in arterial and venous endothelium and smooth muscle of the umbilical cord. The expression of Ang-(1-7) and ACE2 was similar in samples obtained from normal term or preeclamptic pregnancies, except for increased expression of ACE2 in umbilical arterial endothelium in preeclampsia [0.5 (0.5-0.8) vs 0.0 (0.0-0.0), p<0.01]. The uteroplacental location of Ang-(1-7) and ACE2 in pregnancy suggests an autocrine function of Ang-(1-7) in the vasoactive regulation that characterizes placentation and established pregnancy.
G Valdés; L A A Neves; L Anton; J Corthorn; C Chacón; A M Germain; D C Merrill; C M Ferrario; R Sarao; J Penninger; K B Brosnihan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2005-04-25
Journal Detail:
Title:  Placenta     Volume:  27     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    2006 Feb-Mar
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-03-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  200-7     Citation Subset:  IM    
Departamento Nefrología, Facultad Medicina Universidad Católica Santiago, Chile.
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MeSH Terms
Angiotensin I / analysis*,  metabolism
Carboxypeptidases / analysis*,  metabolism
Peptide Fragments / analysis*,  metabolism
Peptidyl-Dipeptidase A
Placenta / chemistry*,  enzymology,  metabolism
Pre-Eclampsia / metabolism
Pregnancy / metabolism*
Pregnancy Complications / enzymology,  metabolism*
Grant Support
Reg. No./Substance:
0/Peptide Fragments; 0/angiotensin I (1-7); 9041-90-1/Angiotensin I; EC 3.4.-/Carboxypeptidases; EC A; EC 3.4.17.-/angiotensin converting enzyme 2

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