Document Detail

Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration.
MedLine Citation:
PMID:  3677501     Owner:  NLM     Status:  MEDLINE    
The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarction treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug.
E Barbieri; R Latini; V D'Aranno; A Fabbri; P Zampieri; G P Trevi; P Zardini
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  10     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-01-14     Completed Date:  1988-01-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  674-6     Citation Subset:  IM    
Istituto Cardiologia e Chirurgia Cardiovascolare, Universita di Verona, Italy.
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MeSH Terms
Amiodarone / administration & dosage,  analogs & derivatives*,  pharmacokinetics*
Injections, Intravenous
Middle Aged
Myocardial Infarction / drug therapy*
Tissue Distribution
Reg. No./Substance:
1951-25-3/Amiodarone; 83409-32-9/desethylamiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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