| Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration. | |
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MedLine Citation:
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PMID: 3677501 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarction treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug. |
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Authors:
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E Barbieri; R Latini; V D'Aranno; A Fabbri; P Zampieri; G P Trevi; P Zardini |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 10 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1987 Nov |
Date Detail:
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Created Date: 1988-01-14 Completed Date: 1988-01-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 674-6 Citation Subset: IM |
Affiliation:
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Istituto Cardiologia e Chirurgia Cardiovascolare, Universita di Verona, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amiodarone
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administration & dosage,
analogs & derivatives*,
pharmacokinetics* Female Humans Injections, Intravenous Male Middle Aged Myocardial Infarction / drug therapy* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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1951-25-3/Amiodarone; 83409-32-9/desethylamiodarone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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