| Distribution of airway narrowing during hyperpnea-induced bronchoconstriction in guinea pigs. | |
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MedLine Citation:
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PMID: 2262449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increasing minute ventilation of dry gas shifts the principal burden of respiratory heat and water losses from more proximal airway to airways farther into the lung. If these local thermal transfers determine the local stimulus for bronchoconstriction, then increasing minute ventilation of dry gas might also extend the zone of airway narrowing farther into the lung during hyperpnea-induced bronchoconstriction (HIB). We tested this hypothesis by comparing tantalum bronchograms in tracheostomized guinea pigs before and during bronchoconstriction induced by dry gas hyperpnea, intravenous methacholine, and intravenous capsaicin. In eight animals subjected to 5 min of dry gas isocapnic hyperpnea [tidal volume (VT) = 2-5 ml, 150 breaths/min], there was little change in the diameter of the trachea or the main stem bronchi up to 0.75 cm past the main carina (zone 1). In contrast, bronchi from 0.75 to 1.50 cm past the main carina (zone 2) narrowed progressively at all minute ventilations greater than or equal to 300 ml/min (VT = 2 ml). More distal bronchi (1.50-3.10 cm past the main carina; zone 3) did not narrow significantly until minute ventilation was raised to 450 ml/min (VT = 3 ml). The estimated VT during hyperpnea needed to elicit a 50% reduction in airway diameter was significantly higher in zone 3 bronchi [4.3 +/- 0.8 (SD) ml] than in zone 2 bronchi (3.5 +/- 1.1 ml, P less than 0.012).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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D W Ray; S Eappen; C Hernandez; M Jackson; L E Alger; A R Leff; J Solway |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 69 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1991-02-01 Completed Date: 1991-02-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1323-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Chicago, Illinois 60637. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchoconstriction / drug effects, physiology* Bronchography Capsaicin / pharmacology Dose-Response Relationship, Drug Guinea Pigs Male Methacholine Compounds / pharmacology Respiration / drug effects, physiology* Respiratory Physiological Phenomena Respiratory System / drug effects Tantalum / diagnostic use Trachea / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-02376/HL/NHLBI NIH HHS; HL-35718/HL/NHLBI NIH HHS; HL-41009/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Methacholine Compounds; 404-86-4/Capsaicin; 7440-25-7/Tantalum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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