Document Detail


Distribution of adenosine deaminase in some rat tissues. Inhibition by ethanol and dimethyl sulfoxide.
MedLine Citation:
PMID:  3829637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The level of adenosine deaminase in various rat tissues has been tested. The enzyme activity of cytosolic fractions decreased in the following order: lung greater than spleen greater than small intestine greater than stomach greater than kidney greater than heart greater than liver greater than skeletal muscle greater than forebrain greater than cerebellum. The enzyme had identical patterns from tissue to tissue with respect to Km, V, and Ki values for ethanol and for dimethyl sulfoxide, with respect to electrophoretic behaviour and to inhibition by antibodies anti-rat brain adenosine deaminase.
Authors:
J J Centelles; R Franco; J Bozal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Comparative biochemistry and physiology. B, Comparative biochemistry     Volume:  86     ISSN:  0305-0491     ISO Abbreviation:  Comp. Biochem. Physiol., B     Publication Date:  1987  
Date Detail:
Created Date:  1987-04-27     Completed Date:  1987-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984730R     Medline TA:  Comp Biochem Physiol B     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Deaminase / antagonists & inhibitors,  metabolism*
Animals
Cytosol / enzymology
Dimethyl Sulfoxide / pharmacology
Ethanol / pharmacology
Kinetics
Male
Nucleoside Deaminases / metabolism*
Rats
Rats, Inbred Strains
Tissue Distribution
Chemical
Reg. No./Substance:
64-17-5/Ethanol; 67-68-5/Dimethyl Sulfoxide; EC 3.5.4.-/Nucleoside Deaminases; EC 3.5.4.4/Adenosine Deaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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