Document Detail


Distribution of acute bowel inflammation determined by technetium-labeled white blood cells in children with inflammatory bowel disease.
MedLine Citation:
PMID:  9589294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Knowledge of the distribution of disease in patients with inflammatory bowel disease is important because it has diagnostic, prognostic, and therapeutic implications. We studied 215 patients with 99mTc-HMPAO-white blood cell scans, of whom 80 had Crohn's disease (CD), 34 had active ulcerative colitis (UC), and 31 were controls. In our 77 cases of active CD, uptake was seen exclusively in the small bowel in 18% of patients, only the large bowel in 44%, and both the large and small bowel in 38% of patients. Discontinuous colitis was seen in 63 of these patients. In the 29 cases of active UC, the uptake involved the entire colon in 50% of patients, extended farther than the sigmoid in 27% of patients, and was limited to the rectosigmoid in 23%. In the 29 cases of active UC, four of the scans incorrectly revealed discontinuous accumulation of 99mTc-HMPAO-WBC. In 31 controls, no significant colonic uptake was seen. Isolated small bowel involvement with CD is observed less frequently in children undergoing 99mTc-HMPAO-WBC scanning than in adults. In children, the segmental distribution of inflammation as depicted with 99mTc-HMPAO-WBC is similar to the radiologic distribution.
Authors:
M Charron; J Fernando del Rosario; S Kocoshis
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Inflammatory bowel diseases     Volume:  4     ISSN:  1078-0998     ISO Abbreviation:  Inflamm. Bowel Dis.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-07-24     Completed Date:  1998-07-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9508162     Medline TA:  Inflamm Bowel Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  84-8     Citation Subset:  IM    
Affiliation:
Department of Radiology, Children's Hospital of Pittsburgh, Pennsylvania 15213, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Child, Preschool
Colitis / physiopathology,  radionuclide imaging
Colitis, Ulcerative / blood,  radionuclide imaging*
Crohn Disease / blood,  radionuclide imaging*
Diagnosis, Differential
Female
Humans
Ileitis / physiopathology,  radionuclide imaging
Leukocytes / radionuclide imaging*
Male
Radiopharmaceuticals / diagnostic use*,  pharmacokinetics
Sensitivity and Specificity
Technetium Tc 99m Exametazime / diagnostic use*,  pharmacokinetics
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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