Document Detail

Distribution of the VLA family of integrins in normal salivary gland and in pleomorphic adenoma.
MedLine Citation:
PMID:  7984519     Owner:  NLM     Status:  MEDLINE    
The extracellular matrix (ECM) and the alterations in tumour stroma affect the biologic behaviour of tumours. These interactions are, at least in part, mediated by the integrin superfamily. In this study we examined the immunohistochemical expression of the "very late activation" (VLA)-integrins in pleomorphic adenomas and in the corresponding normal tissues. Normal salivary gland expresses integrins in the myoepithelial cells (MEC) and in the basal and dark cells of ducts. This pattern is retained in pleomorphic adenoma. Regardless of the straining intensity, these tumour cells have a VLA expression similar to normal basal and dark cells, with only a few cells bearing MEC characteristics. We suggest that the tumour cells of pleomorphic adenoma have a common origin but show different stages of differentiation. Only cells bearing basement membrane (BM)-associated material form typical tubulo-ductal structures.
S Sunardhi-Widyaputra; B Van Damme
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathology, research and practice     Volume:  190     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1995-01-05     Completed Date:  1995-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  600-8     Citation Subset:  IM    
Department of Pathology, Sint Raphael University Hospital, Catholic University of Leuven, Belgium.
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MeSH Terms
Adenoma, Pleomorphic / metabolism*,  pathology
Integrins / classification,  metabolism*
Reference Values
Salivary Gland Neoplasms / metabolism*,  pathology
Salivary Glands / cytology,  metabolism*,  pathology
Tissue Distribution
Reg. No./Substance:

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