Document Detail


Distribution of TP53 mutations among acute leukemias with MLL rearrangements.
MedLine Citation:
PMID:  8824725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute leukemias carrying MLL rearrangements are characterized by a high degree of clinical and immunologic heterogeneity, as demonstrated by variability in their immunophenotype, consistent with lymphoid or myeloid/monoblastic derivation, as well as their occurrence in distinct age groups from infancy to adulthood. Recently, it was shown that inactivation of the TP53 tumor suppressor gene occurs frequently in cases of acute lymphoblastic leukemia carrying MLL rearrangements. In order to assess the extent of TP53 inactivation throughout the immunophenotypic and clinical spectrum of MLL+ acute leukemias, we tested for TP53 mutations 29 cases of MLL+ acute leukemias displaying lymphoid (13 cases) or myeloid/monoblastic (16 cases) features and belonging to different age groups. Mutations were detected in 6/16 myeloid/monoblastic cases and in 3/13 lymphoid cases. Among myeloid/monoblastic leukemias, the TP53 mutations occurred in 3/4 infants, but only in 3/16 cases in other age groups. Overall, our data suggest that (1) TP53 inactivation is a relatively common event in leukemias with MLL rearrangements irrespective of the leukemic phenotype and of the patients' age; (2) at least two genetic lesions (i.e., MLL rearrangement and TP53 mutation) have accumulated in the short time (few weeks after the birth or conception of the child) corresponding to the development of acute leukemias of infancy.
Authors:
C Lanza; G Gaidano; G Cimino; C Pastore; J Nomdedeu; G Volpe; C Vivenza; G Parvis; U Mazza; G Basso; E Madon; F Lo Coco; G Saglio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  15     ISSN:  1045-2257     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-11-22     Completed Date:  1996-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  48-53     Citation Subset:  IM    
Affiliation:
Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Base Sequence
Child
DNA
DNA-Binding Proteins / genetics*
Gene Rearrangement*
Humans
Infant
Leukemia / genetics*
Middle Aged
Molecular Sequence Data
Mutation
Myeloid-Lymphoid Leukemia Protein
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Proto-Oncogenes*
Transcription Factors*
Tumor Suppressor Protein p53 / genetics*
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/MLL protein, human; 0/Transcription Factors; 0/Tumor Suppressor Protein p53; 149025-06-9/Myeloid-Lymphoid Leukemia Protein; 9007-49-2/DNA

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